Piperine exerts anti-seizure effects via the TRPV1 receptor in mice

doi:10.1016/j.ejphar.2013.07.041

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	Piperine exerts anti-seizure effects via the TRPV1 receptor in mice
	Chen, CY; Li, W; Qu, KP; Chen, CR; Chen, CR (reprint author), Fudan Univ, Shanghai Med Coll, Dept Pharmacol, Shanghai 200032, Peoples R China.
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2013-08-15
卷号	714 期号:1-3 页码:288-294
关键词	Piperine Seizure TRPV1 receptor Pentylenetetrazol Capsazepine
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2013.07.041
文献子类	Article
英文摘要	The mechanisms involved in the anti-seizure property of piperine (1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-(E,E)-piperidine, C17H19NO3) are still unclear. Piperine could activate transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor, and the rapid activation of whole-cell currents is antagonized by the competitive TRPV1 antagonist capsazepine. Interestingly, recent studies have reported that TRPV1 may be a novel anti-epileptogenic target which led us to hypothesize that the anti-seizure property of piperine involves the TRPV1 receptor. To test this hypothesis, we examined the effect of piperine on seizures induced in mice and identified the receptors involved in the suppression of seizure caused by maximal electroshock (MES) and pentylenetetrazol (PTZ) models. Piperine, administered at doses of 40 and 80 mg/kg, significantly delayed the onset of myoclonic jerks and generalized clonic seizures, and decreased the seizure stage and mortality compared with the vehicle-treated animals. Piperine also significantly reduced the incidence of MES-induced tonic hindlimb extension (THE) and PTZ-induced Fos immunoreactivity in the dentate gyms. The anti-seizure effects of piperine were blocked by a TRPV1-selective antagonist capsazepine. Taken together, these data support the further investigation of piperine as a TRPV1 agonist for anti-seizure therapy. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
出版地	AMSTERDAM
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [30901797]
语种	英语
WOS记录号	WOS:000323601100037
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125804]
专题	第一临床医学院_期刊论文
通讯作者	Chen, CR (reprint author), Fudan Univ, Shanghai Med Coll, Dept Pharmacol, Shanghai 200032, Peoples R China.
推荐引用方式 GB/T 7714	Chen, CY,Li, W,Qu, KP,et al. Piperine exerts anti-seizure effects via the TRPV1 receptor in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2013,714(1-3):288-294.
APA	Chen, CY,Li, W,Qu, KP,Chen, CR,&Chen, CR .(2013).Piperine exerts anti-seizure effects via the TRPV1 receptor in mice.EUROPEAN JOURNAL OF PHARMACOLOGY,714(1-3),288-294.
MLA	Chen, CY,et al."Piperine exerts anti-seizure effects via the TRPV1 receptor in mice".EUROPEAN JOURNAL OF PHARMACOLOGY 714.1-3(2013):288-294.