Ethosomes, Binary Ethosomes and Transfersomes of Terbinafine Hydrochloride: A Comparative Study

doi:10.1007/s12272-012-0112-0

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	Ethosomes, Binary Ethosomes and Transfersomes of Terbinafine Hydrochloride: A Comparative Study
	Zhang, JP; Wei, YH; Zhou, Y; Li, YQ; Wu, XA; Wu, XA (reprint author), Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Peoples R China.
刊名	ARCHIVES OF PHARMACAL RESEARCH
	2012-01
卷号	35 期号:1 页码:109-117
关键词	Ethosomes Binary ethosomes Transfersomes Transdermal delivery Terbinafine Hydrochloride
ISSN号	0253-6269
DOI	10.1007/s12272-012-0112-0
文献子类	Article
英文摘要	The aim of this study was to compare the skin permeation of ethosomes, binary ethosomes and transfersomes of Terbinafine Hydrochloride (TH) under non-occlusive conditions. These lipid vesicles were prepared and characterized for shape, size, zeta-potential and entrapment efficiency. Franz diffusion cells and confocal laser scanning microscopy (CLSM) were used for the percutaneous absorption studies. The quantity of drug in the skin from ethosomes, binary ethosomes (the weight ratio of ethanol to propylene glycol 7:3, ethanol-PG = 7:3, w/w), and transfersomes was 1.26, 1.51 (p < 0.05), 1.56 (p < 0.01) times higher than that of TB from traditional liposomes (control). The skin deposition of the applied dose (DD%) of TH from ethosomes, binary ethosomes, and transfersomes was 3.34 (p < 0.05), 9.88 (p < 0.01), 2.52 times higher than that of TH from control. The results of CLSM experiments showed that penetration depth and fluorescence intensity of Rhodamine B from binary ethosomes was much greater than that from ethosomes and transfersomes. These results indicated the binary ethosomes (ethanol-PG = 7:3, w/w) most effectively permitted drug penetration through skin; transfersomes made drug easiest to accumulate in the skin. Ethosomes improved drug delivery with greater improvement in skin permeation than improvement in skin deposition.
学科主题	Pharmacology & Pharmacy
出版地	SEOUL
语种	英语
WOS记录号	WOS:000299757300014
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125739]
专题	第一临床医学院_期刊论文
通讯作者	Wu, XA (reprint author), Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, JP,Wei, YH,Zhou, Y,et al. Ethosomes, Binary Ethosomes and Transfersomes of Terbinafine Hydrochloride: A Comparative Study[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35(1):109-117.
APA	Zhang, JP,Wei, YH,Zhou, Y,Li, YQ,Wu, XA,&Wu, XA .(2012).Ethosomes, Binary Ethosomes and Transfersomes of Terbinafine Hydrochloride: A Comparative Study.ARCHIVES OF PHARMACAL RESEARCH,35(1),109-117.
MLA	Zhang, JP,et al."Ethosomes, Binary Ethosomes and Transfersomes of Terbinafine Hydrochloride: A Comparative Study".ARCHIVES OF PHARMACAL RESEARCH 35.1(2012):109-117.