PARP-1 Val762Ala polymorphism, CagA(+) H-pylori infection and risk for gastric cancer in Han Chinese population

doi:10.1007/s11033-008-9336-y

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	PARP-1 Val762Ala polymorphism, CagA(+) H-pylori infection and risk for gastric cancer in Han Chinese population
	Zhang, QB; Li, YM; Li, X; Zhou, W; Shi, B; Chen, H; Yuan, WZ; Li, YM (reprint author), Lanzhou Univ, Hosp 1, Dept Gen Surg, Lanzhou 730000, Peoples R China.
刊名	MOLECULAR BIOLOGY REPORTS
	2009-07
卷号	36 期号:6 页码:1461-1467
关键词	Poly(ADP ribose) polymerase-1 Polymorphism Helicobacter pylori CagA Gastric cancer Risk
ISSN号	0301-4851
DOI	10.1007/s11033-008-9336-y
文献子类	Article
英文摘要	Introduction PARP-1 plays important role in the BER (base excision repair) and maintenance of genomic integrity. Previous study found the Val762Ala genetic variant in the PARP-1 gene contributed to susceptibility of some cancers and decreased PARP-1 enzyme activity in response to oxidative damage. Helicobacter pylori (H. pylori) infection was thought to be one of the major causes of gastric cancer. In this study, we investigated the association between the PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection, and the risk for gastric cancer. Methods This hospital-based, case-control study was performed involving 556 individuals (236 cases with gastric cancer and 320 controls without evidence of neoplasm and gastrointestinal disease) using a PCR-RFLP method. Chi-square test and logistic regression analysis were used to count OR and 95% CI. Results 762Ala/Ala genotype was overrepresented in the cases (16.9%) compared with controls (10.3%), (OR, 1.942; 95% CI, 1.157-3.257, P = 0.011). Multivariate analysis showed that two factors were significantly associated with risk of gastric cancer, including CagA(+) H. pylori infection (OR, 2.562; 95% CI, 1.174-5.240, P = 0.037), PARP-1 762AA genotype (OR, 1.772; 95% CI, 1.065-3.867; P = 0.042). Stratification analysis indicated that among Cag(+) H. pylori positive subjects, 762Ala/Ala carriers had higher risk for developing gastric cancer compared with 762Val/Val carrier (OR, 2.337; 95% CI, 1.148-4.758; P = 0.017). Conclusion PARP-1 762Ala/Ala could be a risk factor for gastric cancer in Han Chinese population; PARP-1 762Val/Ala polymorphism and Cag(+) H. pylori infection jointly contribute to higher risk for gastric cancer.
学科主题	Biochemistry & Molecular Biology
出版地	DORDRECHT
语种	英语
WOS记录号	WOS:000266454500035
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125678]
专题	第一临床医学院_期刊论文
通讯作者	Li, YM (reprint author), Lanzhou Univ, Hosp 1, Dept Gen Surg, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, QB,Li, YM,Li, X,et al. PARP-1 Val762Ala polymorphism, CagA(+) H-pylori infection and risk for gastric cancer in Han Chinese population[J]. MOLECULAR BIOLOGY REPORTS,2009,36(6):1461-1467.
APA	Zhang, QB.,Li, YM.,Li, X.,Zhou, W.,Shi, B.,...&Li, YM .(2009).PARP-1 Val762Ala polymorphism, CagA(+) H-pylori infection and risk for gastric cancer in Han Chinese population.MOLECULAR BIOLOGY REPORTS,36(6),1461-1467.
MLA	Zhang, QB,et al."PARP-1 Val762Ala polymorphism, CagA(+) H-pylori infection and risk for gastric cancer in Han Chinese population".MOLECULAR BIOLOGY REPORTS 36.6(2009):1461-1467.