Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population

doi:10.4238/2015.September.28.15

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	Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population
	Hu, XP; Li, ZQ; Zhou, JY; Yu, ZH; Zhang, JM; Guo, ML; Li, ZQ (reprint author), Northwest Univ Nationalities, Sch Stomatol, Lanzhou, Gansu, Peoples R China.
刊名	GENETICS AND MOLECULAR RESEARCH
	2015
卷号	14 期号:3 页码:11631-11638
关键词	Vitamin D receptor Gene polymorphism Dental caries Case-control study
ISSN号	1676-5680
DOI	10.4238/2015.September.28.15
文献子类	Article
英文摘要	Environmental influences on the development and progression of dental caries are well known; however, there is little evidence of a genetic component imparting susceptibility to dental caries. The aim of this study was to investigate the relationship between a single nucleotide polymorphism in the vitamin D receptor TaqI locus and dental caries susceptibility in a Chinese population. This case-control study was conducted with a case group (264 patients with dental caries from northwestern China) and a control group (219 individuals without dental caries or systemic disease from the same area). DNA was extracted from the peripheral venous blood of the study participants; the distribution of TaqI locus genotypes and allele frequencies was determined via polymerase chain reaction-restriction fragment length polymorphism. The data obtained were statistically analyzed using the Hardy-Weinberg equilibrium and Chi-square test. The frequency of the Tt genotype in the case group (14.0%) was significantly higher than that in the control group (4.3%), as determined using the genotype TT as the reference. The risk of dental caries was increased 3.8-fold in individuals with the heterozygous Tt genotype compared to that in the individuals with the TT genotype. The proportion of the 't' allele in the case group (7.0%) and the control group (2.1%) was observed to be significantly different [P = 0.0003; OR = 3.592, confidence interval 95% (1.790-7.208)]. Our results therefore suggested that the allele 't' might be a genetic factor determining dental caries susceptibility in individuals from the northwest of China.
学科主题	Biochemistry & Molecular Biology ; Genetics & Heredity
出版地	RIBEIRAO PRETO
资助项目	国家自然科学基金项目
项目编号	National Natural Science Fund [31360124/C0309]
语种	英语
WOS记录号	WOS:000362421700124
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179469]
专题	口腔医学院_期刊论文
通讯作者	Li, ZQ (reprint author), Northwest Univ Nationalities, Sch Stomatol, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Hu, XP,Li, ZQ,Zhou, JY,et al. Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(3):11631-11638.
APA	Hu, XP.,Li, ZQ.,Zhou, JY.,Yu, ZH.,Zhang, JM.,...&Li, ZQ .(2015).Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population.GENETICS AND MOLECULAR RESEARCH,14(3),11631-11638.
MLA	Hu, XP,et al."Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population".GENETICS AND MOLECULAR RESEARCH 14.3(2015):11631-11638.