A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation

doi:10.14102/j.cnki.0254-5861.2011-0750

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	A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation
	Yi, YP; Yang, GZ; Guo, ZT; Ai, X; Shang, RF; Liang, JP; Shang, RF (reprint author), Minist Agr, Key Lab New Anim Drug Project Gansu Prov, Beijing, Peoples R China.
刊名	CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
	2015-09
卷号	34 期号:9 页码:1434-1439
关键词	pleuromutilin single-crystal structure antibacterial activities
ISSN号	0254-5861
DOI	10.14102/j.cnki.0254-5861.2011-0750
文献子类	Article
英文摘要	A new pleuromutilin derivative, 14-O-[(4,6-diaminopyrimidine-2-y1) thioacetate] mutilin, was synthesized and structurally characterized by IR, NMR spectra and single-crystal X-ray diffraction. This compound contains a 5-6-8 tricyclic carbon skeleton and a pyrimidine ring. Its crystal is of orthorhombic system, space group P2(1) with a = 10.0237(6), b = 12.6087(7), c = 10.3749(8) angstrom, = 101.48(1)degrees, V= 1284.99(14) angstrom(3), Z = 2, F(000) = 540, D-c(Mg/m(3)) = 1.299, mu= 0.165 mm(-1), R = 0.0649 and wR = 0.0797. The in vitro antibacterial activity study using Oxford cup assay showed this compound displayed more potent activity than pleuromutilin and similar antibacterial activity to that of tiamulin.
学科主题	Chemistry ; Crystallography
出版地	FUJIAN
项目编号	Basic Scientific Research Funds in Central Agricultural Scientific Research Institutions [1610322014003] ; Agricultural Science and Technology Innovation Program (ASTIP)
语种	英语
CSCD记录号	CSCD:5517688
WOS记录号	WOS:000362142500018
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179557]
专题	药学院_期刊论文
通讯作者	Shang, RF (reprint author), Minist Agr, Key Lab New Anim Drug Project Gansu Prov, Beijing, Peoples R China.
推荐引用方式 GB/T 7714	Yi, YP,Yang, GZ,Guo, ZT,et al. A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2015,34(9):1434-1439.
APA	Yi, YP.,Yang, GZ.,Guo, ZT.,Ai, X.,Shang, RF.,...&Shang, RF .(2015).A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,34(9),1434-1439.
MLA	Yi, YP,et al."A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 34.9(2015):1434-1439.