Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles

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	Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles
	Li, L; Zhang, XY; Chen, Y; You, JQ; Qiao, H; Liu, JX; Shi, YB; Zhao, XN; Zhang, XY (reprint author), Lanzhou Univ, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China.
刊名	LATIN AMERICAN JOURNAL OF PHARMACY
	2015
卷号	34 期号:4 页码:773-781
关键词	central composite design desirability function liquid crystalline nanoparticles response surface methodology resveratrol
ISSN号	0326-2383
文献子类	Article
英文摘要	The objective of this study was to prepare and characterize resveratrol liquid crystalline nanoparticles (RES-LCNPs). Response surface methodology (RSM) was employed to optimize the composition of RES-LCNPs. The optimized RES-LCNPs composition with the ratio of GMO (glyceryl monoolein) to RES concentration of 21.7:1, RES concentration of 0.4 g/L and PVA (polivinil alcohol) concentration of 0.91 g/L provided the desired characteristics. The RES-LCNPs presented nearly sphere structure under transmission electron microscopy (TEM), with an average diameter of 50.77 +/- 5.14 nm and zeta potential of -22.6 +/- 1.9 mV. Differential scanning calorimetry (DSC) analyses revealed that RES was present in the LCNPs. The in vitro release profile of the optimized RES-LCNPs exhibited a biphasic pattern with burst release initially and sustained release afterwards. The results indicated that the optimized LCNPs had the potential to be exploited as RES delivery system for achieving sustained release.
学科主题	Pharmacology & Pharmacy
出版地	LA PLATA
语种	英语
WOS记录号	WOS:000355286500019
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179519]
专题	药学院_期刊论文
通讯作者	Zhang, XY (reprint author), Lanzhou Univ, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Li, L,Zhang, XY,Chen, Y,et al. Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2015,34(4):773-781.
APA	Li, L.,Zhang, XY.,Chen, Y.,You, JQ.,Qiao, H.,...&Zhang, XY .(2015).Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles.LATIN AMERICAN JOURNAL OF PHARMACY,34(4),773-781.
MLA	Li, L,et al."Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles".LATIN AMERICAN JOURNAL OF PHARMACY 34.4(2015):773-781.