DNA damage preceding dopamine neuron degeneration in A53T human alpha-synuclein transgenic mice

doi:10.1016/j.bbrc.2016.11.008

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	DNA damage preceding dopamine neuron degeneration in A53T human alpha-synuclein transgenic mice
	Wang, DG; Yu, TY; Liu, YQ; Yan, J; Guo, YL; Jing, YH; Yang, XG; Song, YF; Tian, YX
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2016-12-02
卷号	481 期号:1-2 页码:104-110
关键词	Parkinson's disease DNA damage Neurodegeneration alpha-Synuclein Mouse
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2016.11.008
文献子类	Article
英文摘要	Defective DNA repair has been linked with age-associated neurodegenerative disorders. Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Whether damages to nuclear DNA contribute to neurodegeneration of PD still remain obscure. in this study we aim to explore whether nuclear DNA damage induce dopamine neuron degeneration in A53T human a-Synuclein over expressed mouse model. We investigated the effects of X-ray irradiation on A53T-alpha-Syn MEFs and A53T-alpha-Syn transgene mice. Our results indicate that A53T-alpha-Syn MEFs show a prolonged DNA damage repair process and senescense phenotype. DNA damage preceded onset of motor phenotype in A53T-beta-Syn transgenic mice and decrease the number of nigrostriatal dopaminergic neurons. Neurons of A53T-alpha-Syn transgenic mice are more fragile to DNA damages. (C) 2016 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
出版地	SAN DIEGO
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81472541, 81576312]
语种	英语
WOS记录号	WOS:000389683400017
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188735]
专题	基础医学院_期刊论文
通讯作者	Wang, DG
推荐引用方式 GB/T 7714	Wang, DG,Yu, TY,Liu, YQ,et al. DNA damage preceding dopamine neuron degeneration in A53T human alpha-synuclein transgenic mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,481(1-2):104-110.
APA	Wang, DG.,Yu, TY.,Liu, YQ.,Yan, J.,Guo, YL.,...&Tian, YX.(2016).DNA damage preceding dopamine neuron degeneration in A53T human alpha-synuclein transgenic mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,481(1-2),104-110.
MLA	Wang, DG,et al."DNA damage preceding dopamine neuron degeneration in A53T human alpha-synuclein transgenic mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 481.1-2(2016):104-110.