Simple magnesium catalyst mediated gamma-butyrolactams in desymmetrization of meso-aziridines

doi:10.1039/c6cc02877b

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	Simple magnesium catalyst mediated gamma-butyrolactams in desymmetrization of meso-aziridines
	Li, D; Wang, YJ; Wang, LQ; Wang, J; Wang, PX; Wang, KZ; Lin, L; Liu, DS; Jiang, XX; Yang, DX
刊名	CHEMICAL COMMUNICATIONS
	2016-08-11
卷号	52 期号:62 页码:9640-9643
ISSN号	1359-7345
DOI	10.1039/c6cc02877b
文献子类	Article
英文摘要	The first alpha-sp(2)-carbon of carbonyl compounds attacked catalytic desymmetrization reaction of aziridines is disclosed. A simple in situ generated magnesium catalyst from 3,3'-bromine-8H-BINOL and dibutylmagnesium was employed. It is interesting that the bromine atom on the chiral ligand plays a key role in introducing a high level of enantioselectivities and high reaction efficiency. Both enantiomers of the ring-opening product could be smoothly obtained by using (R)- and (S)-L7.
学科主题	Chemistry
出版地	CAMBRIDGE
资助项目	国家自然科学基金项目 ; 长江学者和创新团队发展计划 ; 高等学校博士学科点专项科研基金 ; 中央高校基本科研业务费专项资金
项目编号	NSFC [21432003, 81473095, 21272102] ; Program for Chang-jiang Scholars and Innovative Research Team in University [PCSIRT: IRT1137] ; ministry of education of China [20130211130005] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-282]
语种	英语
WOS记录号	WOS:000381328500005
资助机构	NSFC ; MOE ; LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179137]
专题	基础医学院_期刊论文
通讯作者	Yang, DX (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.; Liu, DS (reprint author), Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.; Jiang, XX (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
推荐引用方式 GB/T 7714	Li, D,Wang, YJ,Wang, LQ,et al. Simple magnesium catalyst mediated gamma-butyrolactams in desymmetrization of meso-aziridines[J]. CHEMICAL COMMUNICATIONS,2016,52(62):9640-9643.
APA	Li, D.,Wang, YJ.,Wang, LQ.,Wang, J.,Wang, PX.,...&Jiang, XX .(2016).Simple magnesium catalyst mediated gamma-butyrolactams in desymmetrization of meso-aziridines.CHEMICAL COMMUNICATIONS,52(62),9640-9643.
MLA	Li, D,et al."Simple magnesium catalyst mediated gamma-butyrolactams in desymmetrization of meso-aziridines".CHEMICAL COMMUNICATIONS 52.62(2016):9640-9643.