Endomorphin-1 attenuates A beta(42) induced impairment of novel object and object location recognition tasks in mice

doi:10.1016/j.brainres.2015.10.028

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	Endomorphin-1 attenuates A beta(42) induced impairment of novel object and object location recognition tasks in mice
	Zhang, RS; Xu, HJ; Jiang, JH; Han, RW; Chang, M; Peng, YL; Wang, Y; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
刊名	BRAIN RESEARCH
	2015-12-10
卷号	1629 页码:210-220
关键词	Endomorphin-1 Amyloid-beta Alzheimer's disease Recognition memory
ISSN号	0006-8993
DOI	10.1016/j.brainres.2015.10.028
文献子类	Article
英文摘要	A growing body of evidence suggests that the agglomeration of amyloid-beta (A beta) may be a trigger for Alzheimer's disease (AD). Central infusion of A beta 42 can lead to memory impairment in mice. Inhibiting the aggregation of A beta has been considered a therapeutic strategy for AD. Endomorphin-1 (EM-1), an endogenous agonist of mu-opioid receptors, has been shown to inhibit the aggregation of A beta in vitro. In the present study, we investigated whether EM-1 could alleviate the memory-impairing effects of A beta(42) in mice using novel object recognition (NOR) and object location recognition (OLR) tasks. We showed that co-administration of EM-1 was able to ameliorate A beta(42)-induced amnesia in the lateral ventricle and the hippocampus, and these effects could not be inhibited by naloxone, an antagonist of p-opioid receptors. Infusion of EM-1 or naloxone separately into the lateral ventricle had no influence on memory in the tasks. These results suggested that EM-1 might be effective as a drug for AD preventative treatment by inhibiting A beta aggregation directly as a molecular modifier. (C) 2015 Elsevier B.V. All rights reserved.
学科主题	Neurosciences & Neurology
出版地	AMSTERDAM
资助项目	国家自然科学基金项目 ; 国家科技重大专项
项目编号	NSFC [91213302, 81473095] ; National S&T Major Project of China [2012ZX09504001-003]
语种	英语
WOS记录号	WOS:000368308900019
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179081]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, RS,Xu, HJ,Jiang, JH,et al. Endomorphin-1 attenuates A beta(42) induced impairment of novel object and object location recognition tasks in mice[J]. BRAIN RESEARCH,2015,1629:210-220.
APA	Zhang, RS.,Xu, HJ.,Jiang, JH.,Han, RW.,Chang, M.,...&Wang, R .(2015).Endomorphin-1 attenuates A beta(42) induced impairment of novel object and object location recognition tasks in mice.BRAIN RESEARCH,1629,210-220.
MLA	Zhang, RS,et al."Endomorphin-1 attenuates A beta(42) induced impairment of novel object and object location recognition tasks in mice".BRAIN RESEARCH 1629(2015):210-220.