Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility

doi:10.4238/2015.June.1.16

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	Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility
	Li, ZQ; Hu, XP; Zhou, JY; Xie, XD; Zhang, JM; Hu, XP (reprint author), Northwest Univ Nationalities, Sch Stomatol, Lanzhou, Gansu, Peoples R China.
刊名	GENETICS AND MOLECULAR RESEARCH
	2015
卷号	14 期号:2 页码:5986-5993
关键词	Dental caries Number of decayed missing and filled teeth Sequenom MassArray Single-nucleotide polymorphisms
ISSN号	1676-5680
DOI	10.4238/2015.June.1.16
文献子类	Article
英文摘要	We investigated the role of 7 single nucleotide polymorphisms in the carbonic anhydrase (CA) VI gene (rs2274328, rs17032907, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186) and the possible association between these polymorphisms and dental caries susceptibility in a Northwestern Chinese population. We collected samples from 164 high caries experience and 191 very low caries experience and conducted a case-control study according to the number of decayed, missing, and filled teeth index and genotyped the 7 polymorphisms using a 384-well plate format with the Sequenom MassARRAY platform. Individuals carrying the rs17032907 TT genotype were more likely to have an increased risk of dental caries compared with carriers of the C/C genotype in the co-dominant model, with an odds ratio (95% confidence interval) of 2.144 (1.096-4.195). We also found that the haplotype (ACA) (rs2274328, rs17032907 and rs11576766) was associated with a low number of decayed, missing, and filled teeth index with an odds ratio (95% confidence interval) of 0.635 (0.440-0.918). However, we found no association between dental caries susceptibility and the rs2274328, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186 polymorphisms and other haplotypes. The rs17032907 genetic variant and the haplotype (ACA) of CA VI may be associated with dental caries susceptibility.
学科主题	Biochemistry & Molecular Biology ; Genetics & Heredity
出版地	RIBEIRAO PRETO
资助项目	甘肃省国际科技合作计划
项目编号	International Technology Cooperation Projects in Gansu province [2009GS03605]
语种	英语
WOS记录号	WOS:000357189800027
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178999]
专题	基础医学院_期刊论文
通讯作者	Hu, XP (reprint author), Northwest Univ Nationalities, Sch Stomatol, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Li, ZQ,Hu, XP,Zhou, JY,et al. Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(2):5986-5993.
APA	Li, ZQ,Hu, XP,Zhou, JY,Xie, XD,Zhang, JM,&Hu, XP .(2015).Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility.GENETICS AND MOLECULAR RESEARCH,14(2),5986-5993.
MLA	Li, ZQ,et al."Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility".GENETICS AND MOLECULAR RESEARCH 14.2(2015):5986-5993.