Salidroside induces neuronal differentiation of mouse mesenchymal stem cells through Notch and BMP signaling pathways

doi:10.1016/j.fct.2014.05.031

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	Salidroside induces neuronal differentiation of mouse mesenchymal stem cells through Notch and BMP signaling pathways
	Zhao, HB; Qi, SN; Dong, JZ; Ha, XQ; Li, XY; Zhang, QW; Yang, YS; Bai, J; Zhao, L; Zhao, HB (reprint author), Gen Hosp Lanzhou Mil Command PLA, Inst Orthoped, Key Lab Stem Cells & Gene Med Gansu Prov, Lanzhou 730050, Gansu, Peoples R China.
刊名	FOOD AND CHEMICAL TOXICOLOGY
	2014-09
卷号	71 页码:60-67
关键词	Salidroside Mesenchymal stem cells Differentiation Notch signaling pathway Bone morphogenetic proteins (BMP) signaling pathway
ISSN号	0278-6915
DOI	10.1016/j.fct.2014.05.031
文献子类	Article
英文摘要	Salidroside (p-hydroxyphenethyl-beta-D-glucoside, SAL), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. Previous study showed that SAL could induce rat mesenchymal stem cells (MSCs) to differentiate into dopaminergic neurons and induce mouse MSCs D1 to differentiate into neuronal cells. However, the mechanisms of SAL-induced neuronal differentiation of MSCs still need investigation. In this study, we observed the effects of SAL on neuronal differentiation of D1 cells and the possible involvement of Notch and BMP signaling pathways. SAL inhibited the proliferation, induced neuronal phenotypes, and upregulated the expressions of neuronal-specific marker molecules, such as neuronal enolase 2 (Eno2/NSE), microtubule-associated protein 2 (MAP2), and beta 3 class III tubulin (Tubb3/beta-tubulin III) in D1 cells. SAL not only downregulated the expressions of Notch1 and hairy enhancer of split I (Drosophila) (Hes1) but also upregulated the expression of Smad1/5/8 and its phosphorylation (p-Smad 1/5/8). The neuronal differentiation effects of SAL on D1 cells were promoted by a Notch signaling antagonist, DAFT, but attenuated by a BMP signaling pathway antagonist, Noggin. Our findings suggest that SAL might be promising in inducing neuronal differentiation of mouse MSCs mediated by both Notch signaling pathway and BMP signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Food Science & Technology ; Toxicology
出版地	OXFORD
资助项目	国家自然科学基金项目 ; 甘肃省自然科学基金计划
项目编号	National Natural Science Foundation of China [81073156] ; Natural Science Foundation of Gansu Province, China [0710RJZA067]
语种	英语
WOS记录号	WOS:000341466700008
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121721]
专题	基础医学院_期刊论文
通讯作者	Zhao, HB (reprint author), Gen Hosp Lanzhou Mil Command PLA, Inst Orthoped, Key Lab Stem Cells & Gene Med Gansu Prov, Lanzhou 730050, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Zhao, HB,Qi, SN,Dong, JZ,et al. Salidroside induces neuronal differentiation of mouse mesenchymal stem cells through Notch and BMP signaling pathways[J]. FOOD AND CHEMICAL TOXICOLOGY,2014,71:60-67.
APA	Zhao, HB.,Qi, SN.,Dong, JZ.,Ha, XQ.,Li, XY.,...&Zhao, HB .(2014).Salidroside induces neuronal differentiation of mouse mesenchymal stem cells through Notch and BMP signaling pathways.FOOD AND CHEMICAL TOXICOLOGY,71,60-67.
MLA	Zhao, HB,et al."Salidroside induces neuronal differentiation of mouse mesenchymal stem cells through Notch and BMP signaling pathways".FOOD AND CHEMICAL TOXICOLOGY 71(2014):60-67.