The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro | |
Dai, X; Song, HJ; Cui, SG; Wang, T; Liu, Q; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Peoples R China. | |
刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY |
2010-02-25 | |
卷号 | 628期号:1-3页码:42-50 |
关键词 | Endomorphin-1 Endomorphin-2 Deltorphin I Angiogenesis HUVEC |
ISSN号 | 0014-2999 |
DOI | 10.1016/j.ejphar.2009.11.035 |
文献子类 | Article |
英文摘要 | The opioid peptides modulate extensive bioactivities, including pain, cardiovascular response, development and further responses. In the present study, the stimulative effects of endogenous opioid peptides on angiogenesis are evaluated in the proliferation, migration, adhesion and tube formation assays of the human umbilical vein endothelial cell (HUVEC) for the first time. Endomorphin-1, endomorphin-2 and deltorphin I at physiological concentrations could stimulate HUVECs proliferation, migration, adhesion and tube formation in a dose dependent manner; whereas, they exhibited the cytotoxic effects on HUVECs at the higher doses in these assays. Naloxone, the nonselective opioid receptor antagonist, did not influence angiogenesis when it was administrated on its own; but it could antagonize the stimulative effects of the opioid peptides on angiogenesis when it was administrated in combination with the opioid peptides. Taken altogether, the results suggested that endogenous opioid peptides (endomorphin-1 and -2 and deltorphin 1) stimulated angiogenesis at the cellular level, and these effects were mediated by the opioid receptors. These data are significant for potential clinical implementation in future. (C) 2009 Elsevier B.V. All rights reserved. |
学科主题 | Pharmacology & Pharmacy |
出版地 | AMSTERDAM |
资助项目 | 国家自然科学基金项目 ; 高等学校博士学科点专项科研基金 |
项目编号 | National Natural Science Foundation of China [20525206, 20772052] ; Specialized Research Fund for the Doctoral Program in Higher Education Institutions ; Ministry of Education of China |
语种 | 英语 |
WOS记录号 | WOS:000274784500007 |
资助机构 | NSFC ; MOE |
内容类型 | 期刊论文 |
源URL | [http://ir.lzu.edu.cn/handle/262010/121434] |
专题 | 基础医学院_期刊论文 |
通讯作者 | Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Peoples R China. |
推荐引用方式 GB/T 7714 | Dai, X,Song, HJ,Cui, SG,et al. The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,628(1-3):42-50. |
APA | Dai, X.,Song, HJ.,Cui, SG.,Wang, T.,Liu, Q.,...&Wang, R .(2010).The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro.EUROPEAN JOURNAL OF PHARMACOLOGY,628(1-3),42-50. |
MLA | Dai, X,et al."The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro".EUROPEAN JOURNAL OF PHARMACOLOGY 628.1-3(2010):42-50. |
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