Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice

doi:10.1016/j.tox.2008.07.051

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	Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice
	Gong, P; Chen, FX; Ma, GF; Feng, Y; Zhao, QY; Wang, R; Wang, R (reprint author), Lanzhou Univ, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
刊名	TOXICOLOGY
	2008-09-29
卷号	251 期号:1-3 页码:35-44
关键词	Endomorphin 1 Cadmium Oxidative damage Antioxidant
ISSN号	0300-483X
DOI	10.1016/j.tox.2008.07.051
文献子类	Article
英文摘要	The antioxidative capacity of endomorphin 1 (EM1), an endogenous mu-opioid receptor agonist, has been demonstrated by in vivo assays. The present study reports the effect of EM1 on hepatic damage induced by cadmium chloride (Cd(II)) in adult male mouse. Mouse were given intraperitoneally (i.p.) a single dose of Cd(II) (1 mg/kg body weight per day) and the animals were co-administrated with a dose of EM1 (50 mu M/kg body weight per day) for 6 days. Since hepatic damage induced by Cd(II) is related to oxidative stress, lipid peroxidation (LPO), protein carbonyl (PCO), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) were evaluated. The parameter indicating tissue damage such as liver histopathology was also determined. In addition, the concentrations of Cd and zinc (Zn) in the liver were analyzed. The intoxication of Cd(II) lead to the enhanced production of LPO and PCO, treatment with EM1 can effectively ameliorate the increase of LPO and PCO compared to the Cd(II) group. The increased activities of CAT, SOD and the elevated GSH induced by Cd(II) may relate to an adaptive-response to the oxidative damage, the effect of EM1 can restore the elevated antioxidant defense. Our results suggested that the structure features and the ability of chelating metal of EM1 may play a major role in the antioxidant effect of EM1 in vivo and opioid receptors may be involved in the protection of hepatic damage induced by Cd(II). (C) 2008 Elsevier Ireland Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Toxicology
出版地	CLARE
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [20525206, 20621091, 20772052] ; Ministry of Education of China
语种	英语
WOS记录号	WOS:000260367000005
资助机构	NSFC ; MOE
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121391]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Gong, P,Chen, FX,Ma, GF,et al. Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice[J]. TOXICOLOGY,2008,251(1-3):35-44.
APA	Gong, P.,Chen, FX.,Ma, GF.,Feng, Y.,Zhao, QY.,...&Wang, R .(2008).Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice.TOXICOLOGY,251(1-3),35-44.
MLA	Gong, P,et al."Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice".TOXICOLOGY 251.1-3(2008):35-44.