Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials

doi:10.1258/ijsa.2007.007245

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	Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials
	Bai, ZG; Yang, KH; Liu, YL; Tian, JH; Ma, B; Mi, DH; Jiang, L; Tan, JY; Gai, QY; Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, 199,Donggang Rd, Lanzhou 730000, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF STD & AIDS
	2008-04
卷号	19 期号:4 页码:217-221
关键词	azithromycin penicillin G benzathine syphilis randomized clinical trial meta-analysis
ISSN号	0956-4624
DOI	10.1258/ijsa.2007.007245
文献子类	Review
英文摘要	The World Health Organization estimates that at least 12 million people are infected with syphilis in the world. Southeast Asia accounts for 5.8 million; Africa accounts for 3.5 million. There has been controversy in using the two kinds of antibiotics for early syphilis. A systematic review comparing these antibiotics could affect treatment guidelines. The aim of this study was to evaluate the efficacy and safety of azithromycin vs. penicillin G benzathine for early syphilis and a meta-analysis to compare these two kinds of antibiotics for early syphilis. Four randomized controlled trials met the inclusion criteria; 476 patients were evaluated for their cure rate. Cure rates were 95.0% (227/239) for azithromycin and 84.0% (199/237) for penicillin G benzathine. After pooling the data, the difference in efficacy was computed. Cure rate (OR = 1.37), 95% CI (1.05, 1.77) and the risk difference for cure rate between the two drugs were statistically significant. Although the gastrointestinal adverse effect of azithromycin is five times more than the adverse effect of penicillin G benzathine, the differences are not significant. Azithromycin achieved a higher cure rate than penicillin G benzathine in a long follow-up.
学科主题	Immunology ; Infectious Diseases
出版地	LONDON
语种	英语
WOS记录号	WOS:000255834200001
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121382]
专题	基础医学院_期刊论文
通讯作者	Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, 199,Donggang Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Bai, ZG,Yang, KH,Liu, YL,et al. Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials[J]. INTERNATIONAL JOURNAL OF STD & AIDS,2008,19(4):217-221.
APA	Bai, ZG.,Yang, KH.,Liu, YL.,Tian, JH.,Ma, B.,...&Yang, KH .(2008).Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials.INTERNATIONAL JOURNAL OF STD & AIDS,19(4),217-221.
MLA	Bai, ZG,et al."Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials".INTERNATIONAL JOURNAL OF STD & AIDS 19.4(2008):217-221.