Botulinum toxin therapy in the ovalbumin-sensitized rat

doi:10.1159/000107422

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	Botulinum toxin therapy in the ovalbumin-sensitized rat
	Wen, WD; Yuan, F; Wang, JL; Hou, YP; Hou, YP (reprint author), Lanzhou Univ, Dept Anat, Neurobiol Lab, Sch Basic Med Sci, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.
刊名	NEUROIMMUNOMODULATION
	2007
卷号	14 期号:2 页码:78-83
关键词	allergic rhinitis botulinum toxin type A ovalbumin substance P vasoactive intestinal peptide
ISSN号	1021-7401
DOI	10.1159/000107422
文献子类	Article
英文摘要	Objective: The aim of this study was to determine whether intranasal administration of botulinum toxin type A (BTX-A) could relieve the typical symptoms of allergic rhinitis (AR) and alter substance P (SP)- and vasoactive intestinal peptide ( VIP)- immunoreactive (IR) expression in nasal mucosa of AR animals sensitized with ovalbumin ( OVA). Methods: AR was induced by intraperitoneal injection of OVA followed by its repeated intranasal instillation in female Wistar rats. Some AR animals were intranasally treated with a cotton strip containing BTX-A (10 U per nostril) for 1 h. After BTX-A treatment, OVA was repeatedly instilled in AR and AR + BTX-A groups every 2 days for 10 days. Subsequently, nasal symptoms were evaluated, and nasal secretions collected. Finally, the nasal mucosae of all animals were prepared for histological and immunohistochemical assessment. Results: BTX-A administration alleviated typical AR symptoms including rhinorrhea, nasal itching and sneezing, and subsequent intranasal repeated challenge with OVA did not trigger AR symptoms. After BTX-A treatment, inflammatory histological characteristics within the nasal mucosa of AR animals were absent, but atrophy of serous glands was observed. BTX-A decreased dense SP-IR and VIP-IR cells and fibers within and beneath the epithelium, around blood vessels and close to serous glands in AR animals. Conclusion: Local BTX-A treatment is an effective method to reduce AR symptoms. BTX-A decreased the excessive SP-IR and VIP-IR expression induced by OVA. Therefore, BTX-A may affect the nasal mucosa via the suppression of neuropeptides, playing a major role in autonomous mucosal innervation in the pathophysiology of AR. Copyright c 2007 S. Karger AG, Basel.
学科主题	Endocrinology & Metabolism ; Immunology ; Neurosciences & Neurology
出版地	BASEL
语种	英语
WOS记录号	WOS:000249317000003
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121373]
专题	基础医学院_期刊论文
通讯作者	Hou, YP (reprint author), Lanzhou Univ, Dept Anat, Neurobiol Lab, Sch Basic Med Sci, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wen, WD,Yuan, F,Wang, JL,et al. Botulinum toxin therapy in the ovalbumin-sensitized rat[J]. NEUROIMMUNOMODULATION,2007,14(2):78-83.
APA	Wen, WD,Yuan, F,Wang, JL,Hou, YP,&Hou, YP .(2007).Botulinum toxin therapy in the ovalbumin-sensitized rat.NEUROIMMUNOMODULATION,14(2),78-83.
MLA	Wen, WD,et al."Botulinum toxin therapy in the ovalbumin-sensitized rat".NEUROIMMUNOMODULATION 14.2(2007):78-83.