The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone

doi:10.1039/c6md00261g

	The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone
	Chang, Kang 1; Shi, Yanxia 3; Chen, Jianqin 1; He, Zenghui 2; Xu, Zheng 1; Zhao, Zhenjiang 2; Zhu, Weiping 1; Li, Honglin 2; Xu, Yufang 1; Li, Baoju 3
刊名	MEDCHEMCOMM
	2016
卷号	7 期号:9 页码:1849-1857
ISSN号	2040-2503
DOI	10.1039/c6md00261g
通讯作者	Chang, Kang
英文摘要	Plants can develop multifaceted system resistance as a result of infection with pathogens, insects, and some specific microbes or after treatment with specific chemicals.(1) Among them, systemic acquired resistance (SAR) and induced systemic resistance (ISR)(2) are the two most important types. To activate them, a large number of chemical inducers have been exploited based on the SA pathway. However, the JA pathway was rarely investigated for new plant activators. In this study, starting from JA and its analogs, based on the molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound, pyrrolidone, as a new scaffold of plant activators was predicted and a series of 1-phenyl-5-pyrrolidone-3-carboxylic acid derivatives were designed and synthesized. The bioactivity was evaluated, and most of the compounds showed satisfactory activity; especially, compounds 7-11 showed almost no in vitro activity but excellent efficacy against tested diseases, and the prediction of the virtual screening results was also confirmed, which promoted the application of SHAFTS in the development of pesticides.
学科主题	Chemistry, Medicinal
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000384256800017
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/105931]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China 3.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Chang, Kang,Shi, Yanxia,Chen, Jianqin,et al. The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone[J]. MEDCHEMCOMM,2016,7(9):1849-1857.
APA	Chang, Kang.,Shi, Yanxia.,Chen, Jianqin.,He, Zenghui.,Xu, Zheng.,...&Qian, Xuhong.(2016).The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone.MEDCHEMCOMM,7(9),1849-1857.
MLA	Chang, Kang,et al."The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone".MEDCHEMCOMM 7.9(2016):1849-1857.