The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats

doi:10.1211/jpp.60.1.0013

CORC > 中国农业科学院 > 蔬菜花卉研究所

	The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats
	Zhang, Shuang-Qing 1; Zhong, Xu-Ying 1; Chen, Guo-Hua 2; Lu, Wan-Liang 1; Zhang, Qiang 1
刊名	JOURNAL OF PHARMACY AND PHARMACOLOGY
	2008
卷号	60 期号:1 页码:99-105
ISSN号	0022-3573
DOI	10.1211/jpp.60.1.0013
通讯作者	Zhang, Shuang-Qing
英文摘要	The purpose of this study was to evaluate the anti-diabetic effects and pharmacokinetics of bis(maltolato)oxovanadium (BMOV) in rats. The anti-diabetic study was carried out in non-diabetic and diabetic rats by single-dose subcutaneous and intragastric administration. Pharmacokinetic investigation was performed using non-diabetic rats. Results showed that BMOV significantly decreased plasma glucose levels in diabetic rats at all given doses, and restored hyperglycaemic values to normal values after subcutaneous injections at doses of 4 and 8 mg vanadium (V)/kg or after intragastric administration at doses of 14 and 28 mgV/kg, respectively, but did not affect the plasma glucose level in non-diabetic rats. BMOV could be rapidly absorbed, slowly eliminated from plasma, widely distributed in various tissues and accumulated to a greater extent in the femur tissue. The average absolute bioavailability for intragastric administration at a single dose of 3, 6 and 12 mgV/kg was 28.1%, 33.7% and 21.4%, respectively. The presence of the peak vanadium level in the plasma was not coincident with that of the maximum effect of lowering plasma glucose levels. in conclusion, at the present dosing levels and administration routes, BMOV was effective in lowering plasma glucose levels in diabetic rats. BMOV has a promising outlook as an oral glucose-lowering drug.
学科主题	Pharmacology & Pharmacy ; PHARMACOLOGY & PHARMACY
语种	英语
出版者	PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
WOS记录号	WOS:000253152500013
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/102003]
专题	蔬菜花卉研究所
作者单位	1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shuang-Qing,Zhong, Xu-Ying,Chen, Guo-Hua,et al. The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2008,60(1):99-105.
APA	Zhang, Shuang-Qing,Zhong, Xu-Ying,Chen, Guo-Hua,Lu, Wan-Liang,&Zhang, Qiang.(2008).The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats.JOURNAL OF PHARMACY AND PHARMACOLOGY,60(1),99-105.
MLA	Zhang, Shuang-Qing,et al."The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats".JOURNAL OF PHARMACY AND PHARMACOLOGY 60.1(2008):99-105.