Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides

doi:10.1016/j.ejmech.2009.01.012

CORC > 中国农业科学院 > 蔬菜花卉研究所

	Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides
	Liu, Xing-Hai 2; Shi, Yan-Xia 1; Ma, Yi 2; Zhang, Chuan-Yu 2; Dong, Wei-Li 2; Pan, Li 2; Wang, Bao-Lei 2; Li, Bao-Ju 1; Li, Zheng-Ming 2
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2009
卷号	44 期号:7 页码:2782-2786
关键词	Cyclopropanecarboxamide 1,3,4-Thiadiazole Antifungal activity 3D-QSAR Synthesis
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2009.01.012
通讯作者	Liu, Xing-Hai
英文摘要	A series of cyclopropanecarboxamide were prepared and tested for antifungal activity in vivo. The preliminary bioassays indicated that some compounds are comparable to the commercial fungicides. To further explore the comprehensive structure-activity relationship on the basis of fungicidal activity data, comparative molecular field analysis (CoMFA) was performed, and a statistically reliable model with good predictive power (r(2) = 0.8, q(2) = 0.516) was achieved. Based on the CoMFA, compound 7p was designed and synthesized, which was found to display a good antifungal activity (79.38%) as 7g and 7h. (C) 2009 Elsevier Masson SAS. All rights reserved.
学科主题	Chemistry, Medicinal ; CHEMISTRY, MEDICINAL
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000266524900003
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101989]
专题	蔬菜花卉研究所
作者单位	1.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing, Peoples R China 2.Nankai Univ, Tianjin Key Lab Pesticide Sci, Natl Pesticidal Engn Ctr Tianjin, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xing-Hai,Shi, Yan-Xia,Ma, Yi,et al. Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2009,44(7):2782-2786.
APA	Liu, Xing-Hai.,Shi, Yan-Xia.,Ma, Yi.,Zhang, Chuan-Yu.,Dong, Wei-Li.,...&Li, Zheng-Ming.(2009).Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,44(7),2782-2786.
MLA	Liu, Xing-Hai,et al."Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44.7(2009):2782-2786.