Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp HBDN08 with antifungal activity

doi:10.1016/j.biortech.2010.06.052

CORC > 中国农业科学院 > 蔬菜花卉研究所

	Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp HBDN08 with antifungal activity
	Zhang, Ji 1; Wang, Xiang-Jing 1; Yan, Yi-Jun 1; Jiang, Ling 1; Wang, Ji-Dong 1; Li, Bao-Ju 2; Xiang, Wen-Sheng 1
刊名	BIORESOURCE TECHNOLOGY
	2010
卷号	101 期号:21 页码:8383-8388
关键词	Actinoplanes sp HBDN08 Antifungal activity 5-Hydroxyl-5-methy1-2-hexenoic acid
ISSN号	0960-8524
DOI	10.1016/j.biortech.2010.06.052
通讯作者	Zhang, Ji
英文摘要	A bioactivity-guided approach was employed to isolate and determine the chemical identity of bioactive constituents with antifungal activity from Actinoplanes sp. HBDN08. The structure of the antifungal metabolite was elucidated as 5-hydroxyl-5-methyl-2-hexenoic acid on the basis of spectral analysis. This compound showed strong in vitro antifungal activity against Botrytis cinerea, Cladosporium cucumerinum and Corynespora cassiicola, with an IC(50) of 32.45, 27.17, and 30.66 mg/L, respectively; however, it only moderately inhibited hyphal growth of Rhizoctonia solani with an IC(50) of 61.64 mg/L. The in vivo antifungal activity under greenhouse conditions demonstrated that 5-hydroxyl-5-methyl-2-hexenoic acid could effectively control the diseases caused by B. cinerea, C. cucumerinum and C. cassiicola with 71.42%, 78.63% and 65.13% control values at 350 mg/L, respectively. This strong antifungal activity suggests that 5-hydroxyl-5-methyl-2-hexenoic acid might be a promising candidate for new antifungal agents. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels ; AGRICULTURAL ENGINEERING ; BIOTECHNOLOGY & APPLIED MICROBIOLOGY ; ENERGY & FUELS
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000280570900053
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101970]
专题	蔬菜花卉研究所
作者单位	1.NE Agr Univ, Sch Life Sci, Harbin 150030, Heilongjiang, Peoples R China 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ji,Wang, Xiang-Jing,Yan, Yi-Jun,et al. Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp HBDN08 with antifungal activity[J]. BIORESOURCE TECHNOLOGY,2010,101(21):8383-8388.
APA	Zhang, Ji.,Wang, Xiang-Jing.,Yan, Yi-Jun.,Jiang, Ling.,Wang, Ji-Dong.,...&Xiang, Wen-Sheng.(2010).Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp HBDN08 with antifungal activity.BIORESOURCE TECHNOLOGY,101(21),8383-8388.
MLA	Zhang, Ji,et al."Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp HBDN08 with antifungal activity".BIORESOURCE TECHNOLOGY 101.21(2010):8383-8388.