Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety

doi:10.1111/j.1747-0285.2011.01205.x

CORC > 中国农业科学院 > 蔬菜花卉研究所

	Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety
	Liu, Xing-Hai 1; Pan, Li 2; Ma, Yi 2; Weng, Jian-Quan 1; Tan, Cheng-Xia 1; Li, Yong-Hong 2; Shi, Yan-Xia 3; Li, Bao-Ju 3; Li, Zheng-Ming 2; Zhang, Yong-Gang 4
刊名	CHEMICAL BIOLOGY & DRUG DESIGN
	2011
卷号	78 期号:4 页码:689-694
关键词	N,N '-diacylhydrazines 2-(2,4-dichlorophenoxy)propane microwave synthesis herbicidal activity fungicidal activity plant growth regulatory activity 3D-QSAR
ISSN号	1747-0277
DOI	10.1111/j.1747-0285.2011.01205.x
通讯作者	Liu, Xing-Hai
英文摘要	A series of new N,N'-diacylhydrazine derivatives were synthesized efficiently under microwave irradiation. Their structures were characterized by (1)H NMR, MS, and elemental analysis. Various biological activities of these compounds were tested. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. In addition, favorable in vivo fungicidal activities were also found of these compounds against Cladosporium cucumerinum, Corynespora cassiicola, Sclerotinia sclerotiorum( Lib.) de Bary, Erysiphe cichoracearum, and Colletotrichum orbiculare (Berk aLMont) Arx. All compounds displayed excellent plant growth regulatory activities: 100% inhibition was achieved against the radicle growth of cucumber. To further investigate the structure-activity relationship, comparative molecular field analysis was performed on the basis of herbicidal activity data, resulting in a statistically reliable model with good predictive power (r(2) = 0.913, q(2) = 0.556). Based on the calculation, five additional novel compounds were designed and synthesized. Satisfyingly, compound 4u displayed excellent herbicidal activity (94.7%) at 1500 g/ha, although it is less active than 2,4-D. Meanwhile, this compound also exhibited good fungicidal activity against C. orbiculare (Berk aLMont) Arx (82.16%).
学科主题	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; BIOCHEMISTRY & MOLECULAR BIOLOGY ; CHEMISTRY, MEDICINAL
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000294922600021
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101945]
专题	蔬菜花卉研究所
作者单位	1.Zhejiang Univ Technol, Inst Pesticide, Hangzhou 310014, Zhejiang, Peoples R China 2.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 3.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100014, Peoples R China 4.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xing-Hai,Pan, Li,Ma, Yi,et al. Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2011,78(4):689-694.
APA	Liu, Xing-Hai.,Pan, Li.,Ma, Yi.,Weng, Jian-Quan.,Tan, Cheng-Xia.,...&Zhang, Yong-Gang.(2011).Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety.CHEMICAL BIOLOGY & DRUG DESIGN,78(4),689-694.
MLA	Liu, Xing-Hai,et al."Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety".CHEMICAL BIOLOGY & DRUG DESIGN 78.4(2011):689-694.