Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety

doi:10.1016/j.bmcl.2011.09.068

CORC > 中国农业科学院 > 蔬菜花卉研究所

	Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety
	Cui, Zining 1,2; Yang, Xinling 2; Shi, Yanxia 3; Uzawa, Hirotaka 4; Cui, Jingrong 5; Dohi, Hirofumi 1; Nishida, Yoshihiro 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2011
卷号	21 期号:23 页码:7193-7196
关键词	Synthesis Glycosyl hydrazine Glycosyl hydrazone Antitumor activity Antifungal activity Toxicity
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2011.09.068
通讯作者	Cui, Zining
英文摘要	Assuming that the water solubility of our previous hydrazone derivatives would improve after modification with sugars while keeping or modulating their notable biological activities, we designed and synthesized some glycosyl hydrazine and hydrazone derivatives. Bioassay results indicated that the antitumor activity of our previously prepared hydrazones reduced or disappeared after modification with sugars. On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi. Obviously, a small sugar can change the biological activity of hydrazones significantly. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Medicinal ; Chemistry, Organic ; CHEMISTRY, MEDICINAL ; CHEMISTRY, ORGANIC
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000296717600053
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101942]
专题	蔬菜花卉研究所
作者单位	1.Chiba Univ, Grad Sch Adv Integrat Sci, Dept Nanobiol, Chiba 2718510, Japan 2.China Agr Univ, Coll Sci, Dept Appl Chem, Beijing 100193, Peoples R China 3.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China 4.Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Tsukuba, Ibaraki 3058565, Japan 5.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Cui, Zining,Yang, Xinling,Shi, Yanxia,et al. Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(23):7193-7196.
APA	Cui, Zining.,Yang, Xinling.,Shi, Yanxia.,Uzawa, Hirotaka.,Cui, Jingrong.,...&Nishida, Yoshihiro.(2011).Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(23),7193-7196.
MLA	Cui, Zining,et al."Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.23(2011):7193-7196.