| Synthesis and antifungal evaluation of a series of maleimides | |
| Chen, Xiao-Long1; Zhang, Li-Jun1; Li, Fu-Ge1; Fan, Yong-Xian1; Wang, Wei-Ping2; Li, Bao-Ju2; Shen, Yin-Chu1 | |
| 刊名 | PEST MANAGEMENT SCIENCE
 |
| 2015 | |
| 卷号 | 71期号:3页码:433-440 |
| 关键词 | maleimides Sclerotinia sclerotiorum antifungal agents fungicide resistance |
| ISSN号 | 1526-498X |
| DOI | 10.1002/ps.3824 |
| 通讯作者 | Chen, Xiao-Long |
| 英文摘要 | BACKGROUNDMaleimides, both natural and synthesised, have good biological activities. In a continuous effort to discover new maleimides with good antifungal activities, the authors have synthesised a series of 3,4-dichloro-, 3-methyl and non-substituted maleimides based on previous studies. The compounds were biologically evaluated against the fungal pathogen Sclerotinia sclorotiorum.RESULTSOf the 63 compounds evaluated, 25 compounds had interesting inhibitory potency with EC50 < 10 mu g mL(-1). N-(3,5-Dichlorophenyl)-3,4-dichloromaleimide (EC50 = 1.11 mu g mL(-1)) and N-octyl-3-methylmaleimide (EC50 = 1.01 mu g mL(-1)) were more potent than the commercial fungicide dicloran (EC50 = 1.72 mu g mL(-1)). The results showed that compounds exhibiting log P values within the range 2.4-3.0 displayed the best results in terms of fungicidal activity, and this seemed, therefore, to be the optimum range for this physicochemical parameter.CONCLUSIONThe present work demonstrates that some maleimides can be used as potential lead compounds for developing novel antifungal agents against S. sclerotiorum. (c) 2014 Society of Chemical Industry |
| 学科主题 | Agronomy ; Entomology |
| 语种 | 英语 |
| 出版者 | WILEY-BLACKWELL |
| WOS记录号 | WOS:000349998100011 |
| 内容类型 | 期刊论文 |
| 源URL | [http://111.203.20.206/handle/2HMLN22E/101804]  |
| 专题 | 蔬菜花卉研究所 |
| 作者单位 | 1.Zhejiang Univ Technol, Inst Fermentat Engn, Coll Biol & Environm Engn, Hangzhou 310014, Zhejiang, Peoples R China 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100193, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xiao-Long,Zhang, Li-Jun,Li, Fu-Ge,et al. Synthesis and antifungal evaluation of a series of maleimides[J]. PEST MANAGEMENT SCIENCE,2015,71(3):433-440. |
| APA | Chen, Xiao-Long.,Zhang, Li-Jun.,Li, Fu-Ge.,Fan, Yong-Xian.,Wang, Wei-Ping.,...&Shen, Yin-Chu.(2015).Synthesis and antifungal evaluation of a series of maleimides.PEST MANAGEMENT SCIENCE,71(3),433-440. |
| MLA | Chen, Xiao-Long,et al."Synthesis and antifungal evaluation of a series of maleimides".PEST MANAGEMENT SCIENCE 71.3(2015):433-440. |
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