Determination of three beta-blockers by capillary electrophoresis with end-column electrochemical detection

	Determination of three beta-blockers by capillary electrophoresis with end-column electrochemical detection
	Bai XX ; You TY ; Sun HW ; Yang XR ; Wang EK
刊名	electroanalysis
	2000
卷号	12 期号:17 页码:1379-1382
关键词	SUPERCRITICAL-FLUID CHROMATOGRAPHY IONIZATION MASS-SPECTROMETRY IMPROVED CHIRAL SEPARATION ZONE ELECTROPHORESIS STATIONARY PHASES LIQUID DRUGS CYCLODEXTRIN PROPRANOLOL GAS
ISSN号	1040-0397
通讯作者	yang xr
中文摘要	three beta -blockers (propranolol, timolol, acebutolol) were separated by capillary electrophoresis (ce) and detected by end-column electrochemical detection (ec). in the present work, a carbon fiber (33 mum) electrode was used as the working electrode. the effect of the buffer concentration, buffer ph, detection potential and separation voltage on the separation of analytes and behavior of electrochemical detection was systematically investigated. the optimum conditions determined were as following: 40 cm length, 25 mum i.d. capillary; 17.5 kv separation voltage; 2 s injection at 15 kv; 70mm phosphate buffer, ph 3.5; detection potential + 1.2v (vs. ag/agcl). under these conditions, the linear ranges of beta -blockers were over three orders of magnititude and the low detection limit of 10(-8)m was obtained. this method was also applied to detect the simulated urine sample.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000165618800006
公开日期	2010-11-04
内容类型	期刊论文
源URL	[http://202.98.16.49/handle/322003/19455]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Bai XX,You TY,Sun HW,et al. Determination of three beta-blockers by capillary electrophoresis with end-column electrochemical detection[J]. electroanalysis,2000,12(17):1379-1382.
APA	Bai XX,You TY,Sun HW,Yang XR,&Wang EK.(2000).Determination of three beta-blockers by capillary electrophoresis with end-column electrochemical detection.electroanalysis,12(17),1379-1382.
MLA	Bai XX,et al."Determination of three beta-blockers by capillary electrophoresis with end-column electrochemical detection".electroanalysis 12.17(2000):1379-1382.