Assessment of genotoxic effects of flumorph by the comet assay in mice organs

doi:10.1177/0960327111417268

CORC > 中国农业科学院 > 植物保护研究所

	Assessment of genotoxic effects of flumorph by the comet assay in mice organs
	Zhang, T.1; Zhao, Q.1; Zhang, Y.2; Ning, J.1
刊名	HUMAN & EXPERIMENTAL TOXICOLOGY
	2014
卷号	33 期号:3 页码:224-229
关键词	flumorph alkaline comet assay genotoxicity DNA damage
ISSN号	0960-3271
DOI	10.1177/0960327111417268
通讯作者	Zhang, T.
英文摘要	The present study investigated the genotoxic effects of flumorph in various organs (brain, liver, spleen, kidney and sperm) of mice. The DNA damage, measured as comet tail length (mu m), was determined using the alkaline comet assay. The comet assay is a sensitive assay for the detection of genotoxicity caused by flumorph using mice as a model. Statistically significant increases in comet assay for both dose-dependent and duration-dependent DNA damage were observed in all the organs assessed. The organs exhibited the maximum DNA damage in 96 h at 54 mg/kg body weight. Brain showed maximum DNA damage followed by spleen > kidney > liver > sperm. Our data demonstrated that flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen.
学科主题	Toxicology
语种	英语
出版者	SAGE PUBLICATIONS LTD
WOS记录号	WOS:000330824700001
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/11985]
专题	植物保护研究所
作者单位	1.Chinese Acad Agr Sci, Inst Plant Protect, Key Lab Pesticide Chem & Applicat, Minist Agr, Beijing 100193, Peoples R China 2.Univ Sci & Technol Beijing, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhang, T.,Zhao, Q.,Zhang, Y.,et al. Assessment of genotoxic effects of flumorph by the comet assay in mice organs[J]. HUMAN & EXPERIMENTAL TOXICOLOGY,2014,33(3):224-229.
APA	Zhang, T.,Zhao, Q.,Zhang, Y.,&Ning, J..(2014).Assessment of genotoxic effects of flumorph by the comet assay in mice organs.HUMAN & EXPERIMENTAL TOXICOLOGY,33(3),224-229.
MLA	Zhang, T.,et al."Assessment of genotoxic effects of flumorph by the comet assay in mice organs".HUMAN & EXPERIMENTAL TOXICOLOGY 33.3(2014):224-229.