A 90 Day Safety Assessment of Genetically Modified Rice Expressing Cry1Ab/1Ac Protein using an Aquatic Animal Model

doi:10.1021/jf5055547

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	A 90 Day Safety Assessment of Genetically Modified Rice Expressing Cry1Ab/1Ac Protein using an Aquatic Animal Model
	Zhu, Hao-Jun 1,2; Chen, Yi 2; Li, Yun-He 2; Wang, Jia-Mei 1,2; Ding, Jia-Tong 1; Chen, Xiu-Ping 2; Peng, Yu-Fa 2
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2015
卷号	63 期号:14 页码:3627-3633
关键词	transgenic rice Bt protein frog safety assessment nontarget effect
ISSN号	0021-8561
DOI	10.1021/jf5055547
通讯作者	Zhu, Hao-Jun
英文摘要	In fields of transgenic Bt rice, frogs are exposed to Bt proteins through consumption of both target and nontarget insects. In the present study, we assessed the risk posed by transgenic rice expressing a Cry1Ab/1Ac fusion protein (Huahui 1, HH1) on the development of Xenopus laevis. For 90 days, froglets were fed a diet with 30% HH1 rice, 30% parental rice (Minghui 63, MH63), or no rice as a control. Body weight and length were measured every 15 days. After sacrificing the froglets, we performed a range of biological, clinical, and pathological assessments. No significant differences were found in body weight (on day 90: 27.7 +/- 2.17, 27.4 +/- 2.40, and 27.9 +/- 1.67 g for HH1, MH63, and control, respectively), body length (on day 90: 60.2 +/- 1.55, 59.3 +/- 2.33, and 59.7 +/- 1.64 mm for HH1, MH63, and control, respectively), animal behavior, organ weight, liver and kidney function, or the microstructure of some tissues between the froglets fed on the HH1-containing diet and those fed on the MH63-containing or control diets. This indicates that frog development was not adversely affected by dietary intake of Cry1Ab/1Ac protein.
学科主题	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000353178100002
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/11730]
专题	植物保护研究所
作者单位	1.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Jiangsu, Peoples R China 2.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Hao-Jun,Chen, Yi,Li, Yun-He,et al. A 90 Day Safety Assessment of Genetically Modified Rice Expressing Cry1Ab/1Ac Protein using an Aquatic Animal Model[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2015,63(14):3627-3633.
APA	Zhu, Hao-Jun.,Chen, Yi.,Li, Yun-He.,Wang, Jia-Mei.,Ding, Jia-Tong.,...&Peng, Yu-Fa.(2015).A 90 Day Safety Assessment of Genetically Modified Rice Expressing Cry1Ab/1Ac Protein using an Aquatic Animal Model.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,63(14),3627-3633.
MLA	Zhu, Hao-Jun,et al."A 90 Day Safety Assessment of Genetically Modified Rice Expressing Cry1Ab/1Ac Protein using an Aquatic Animal Model".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 63.14(2015):3627-3633.