Nicotinic Acetylcholine Receptor Gene Family of the Pea Aphid, Acyrthosiphon pisum

CORC > 中国农业科学院 > 植物保护研究所

	Nicotinic Acetylcholine Receptor Gene Family of the Pea Aphid, Acyrthosiphon pisum
	Liu Yipeng 1; Lin Kejian 1; Liu Yang 1; Gui Furong 2; Wang Guirong 1
刊名	Journal of Integrative Agriculture
	2013
卷号	12 期号:11 页码:2083-2091
关键词	Acyrthosiphon pisum nicotinic acetylcholine receptor alternative splicing expression proifle
ISSN号	2095-3119
英文摘要	The nicotinic acetylcholine receptors (nAchRs) are cholinergic receptors that form ligand-gated ion channels by ifve subunits in insect and vertebrate nervous systems. The insect nAChR is the molecular target of a class of insecticides, neonicotinoids. Here, we identiifed and cloned 11 candidate nAChR subunit genes in Acyrthosiphon pisum using genome-based bioinformatics combined modern molecular techniques. Most A. pisum nAChRs including α1, α2, α3, α4, α6, α8, and β1 show highly sequence identities with the counterparts of other insects examined. Expression proifles analysis showed that all subunit genes were expressed in adult head. At least two subunits have alternative splicing that obviously increase A. pisum nicotinic receptor diversity. This study will be invaluable for exploring the molecular mechanisms of neonicotinoid-like insecticides in sucking pests, and for ultimately establishing the screening platform of novel insecticides.
学科主题	基础医学 ; 内科学
语种	中文
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/11129]
专题	植物保护研究所
作者单位	1.Institute of Plant Protection, Chinese Academy of Agricultural Sciences, State Key Laboratory for Biology of Plant Diseases and Insect Pests, Beijing, 100193 2.College of Plant Protection, Yunnan Agricultural University, Yunnan, 650201
推荐引用方式 GB/T 7714	Liu Yipeng,Lin Kejian,Liu Yang,et al. Nicotinic Acetylcholine Receptor Gene Family of the Pea Aphid, Acyrthosiphon pisum[J]. Journal of Integrative Agriculture,2013,12(11):2083-2091.
APA	Liu Yipeng,Lin Kejian,Liu Yang,Gui Furong,&Wang Guirong.(2013).Nicotinic Acetylcholine Receptor Gene Family of the Pea Aphid, Acyrthosiphon pisum.Journal of Integrative Agriculture,12(11),2083-2091.
MLA	Liu Yipeng,et al."Nicotinic Acetylcholine Receptor Gene Family of the Pea Aphid, Acyrthosiphon pisum".Journal of Integrative Agriculture 12.11(2013):2083-2091.