A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat

doi:10.1038/ng.3439

	A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat
	Moore, John W.1; Herrera-Foessel, Sybil 2; Lan, Caixia 2; Schnippenkoetter, Wendelin 1; Ayliffe, Michael 1; Huerta-Espino, Julio 3; Lillemo, Morten 4; Viccars, Libby 1; Milne, Ricky 1; Periyannan, Sambasivam 1
刊名	NATURE GENETICS
	2015
卷号	47 期号:12 页码:1494-+
ISSN号	1061-4036
DOI	10.1038/ng.3439
通讯作者	Moore, John W.
英文摘要	As there are numerous pathogen species that cause disease and limit yields of crops, such as wheat (Triticum aestivum), single genes that provide resistance to multiple pathogens are valuable in crop improvement(1,2). The mechanistic basis of multi-pathogen resistance is largely unknown. Here we use comparative genomics, mutagenesis and transformation to isolate the wheat Lr67 gene, which confers partial resistance to all three wheat rust pathogen species and powdery mildew. The Lr67 resistance gene encodes a predicted hexose transporter (LR67res) that differs from the susceptible form of the same protein (LR67sus) by two amino acids that are conserved in orthologous hexose transporters. Sugar uptake assays show that LR67sus, and related proteins encoded by homeoalleles, function as high-affinity glucose transporters. LR67res exerts a dominant-negative effect through heterodimerization with these functional transporters to reduce glucose uptake. Alterations in hexose transport in infected leaves may explain its ability to reduce the growth of multiple biotrophic pathogen species.
学科主题	Genetics & Heredity
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000365813200024
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/4623]
专题	作物科学研究所_分子生物学系
作者单位	1.Commonwealth Sci & Ind Res Org CSIRO Agr, Canberra, ACT, Australia 2.Int Maize & Wheat Improvement Ctr CIMMYT, Mexico City, DF, Mexico 3.Campo Expt Valle Mexico INIFAP, Chapingo, Edo De Mexico, Mexico 4.Norwegian Univ Life Sci, Dept Plant Sci, As, Norway 5.Chinese Acad Agr Sci, Inst Crop Sci, Natl Key Facil Crop Gene Resources & Genet Improv, Beijing 100193, Peoples R China 6.Univ Sydney, Plant Breeding Inst Cobbitty, Narellan, Australia 7.Univ Newcastle, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia
推荐引用方式 GB/T 7714	Moore, John W.,Herrera-Foessel, Sybil,Lan, Caixia,et al. A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat[J]. NATURE GENETICS,2015,47(12):1494-+.
APA	Moore, John W..,Herrera-Foessel, Sybil.,Lan, Caixia.,Schnippenkoetter, Wendelin.,Ayliffe, Michael.,...&Lagudah, Evans.(2015).A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat.NATURE GENETICS,47(12),1494-+.
MLA	Moore, John W.,et al."A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat".NATURE GENETICS 47.12(2015):1494-+.