Interaction between La3+ and MP-11 in the physiological solution

	Interaction between La3+ and MP-11 in the physiological solution
	Guo SF ; Zhou Q ; Lu TH ; Ding XL ; Huang XH
刊名	electrochimica acta
	2007
卷号	52 期号:5 页码:2032-2038
关键词	HEART CYTOCHROME-C DIRECT ELECTROCHEMISTRY HORSERADISH-PEROXIDASE ELECTROCATALYTIC REDUCTION ELECTRON-TRANSFER GOLD ELECTRODE NICKEL(II) PORPHYRINS NONPLANAR DISTORTION GRAPHITE-ELECTRODES MOLECULAR-DYNAMICS
ISSN号	0013-4686
通讯作者	huang xh
中文摘要	in this paper, the interaction between la3+ and microperoxidase-11 (mp-11) in the imitated physiological solution was investigated with the electrochemical method, circular dichroism (cd) and ultraviolet-visible (uv-vis) absorption spectroscopy. it was found that the interaction ways between la3+ and mp-11 are different with increasing the molar ratio of la3+ and mp-11. when the molar ratio of la3+ and mp-11 is less than 2, la3+ mainly interacts with the metacetonic acid group of the heme group in the mp-11 molecules, causing the increase in the non-planarity of the porphyrin cycle in the heme group and the decrease in the content of the random coil conformation of mp-11. these structural changes would increase the exposure extent of the electrochemical active center of mp-11 and thus, la3+ can promote the electrochemical reaction of mp-11 and its electrocatalytic activity for the reduction of h2o2 at the glassy carbon (gc) electrode. however, when the molar ratio of la3+ and mp-11 is larger than 3, except binding to the carbonyl oxygen of the metacetonic acid group in the heme group, la3+ interacts also with the oxygen-containing groups of the amides in the polypeptide chains of the mp-11 molecules, leading to the increase in the contents of the random coil conformation in the peptide of the mp-11 molecule, comparing with that for the molar ratio of less than 2.
收录类别	SCI
语种	英语
WOS记录号	WOS:000243647700026
公开日期	2010-07-13
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/14571]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Guo SF,Zhou Q,Lu TH,et al. Interaction between La3+ and MP-11 in the physiological solution[J]. electrochimica acta,2007,52(5):2032-2038.
APA	Guo SF,Zhou Q,Lu TH,Ding XL,&Huang XH.(2007).Interaction between La3+ and MP-11 in the physiological solution.electrochimica acta,52(5),2032-2038.
MLA	Guo SF,et al."Interaction between La3+ and MP-11 in the physiological solution".electrochimica acta 52.5(2007):2032-2038.