Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice

doi:10.1021/jf103749r

	Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice
	Yang, Xiushi 1,2; Dong, Chuan 2; Ren, Guixing 1
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2011
卷号	59 期号:4 页码:1138-1144
关键词	Soyasaponins alcohol hepatotoxicity mice
ISSN号	0021-8561
DOI	10.1021/jf103749r
通讯作者	Yang, Xiushi
英文摘要	The protective effects of soyasaponins-rich extract (SRE) from soybean against acute alcohol-induced hepatotoxicity were first investigated in the Institute of Cancer Research mice. Administration of SRE prior to alcohol significantly prevented the increases in serum aspartate transaminase, alanine transaminase, alkaline phosphatase, and lactate dehydrogenase caused by alcohol, as well as hepatic triglyceride, total cholesterol, and malondialdehyde levels. Mice treated with SRE showed a better profile of the antioxidant system with normal superoxide dismutase, glutathione S-transferase, and glutathione peroxidase activities, which were associated with the increase of hepatic glutathione levels relative to the acute alcohol-treated group. Supplement of SRE prevented alcohol-induced hepatic steatosis necrosis, inflammation, and swelling, as indicated by liver histopathological studies. All of these findings demonstrate that SRE has protective effects on acute alcohol-induced liver damage.
学科主题	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology ; AGRICULTURE, MULTIDISCIPLINARY ; CHEMISTRY, APPLIED ; FOOD SCIENCE & TECHNOLOGY
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000287297100013
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/5342]
专题	作物科学研究所_种质资源保存与研究中心
作者单位	1.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China 2.Shanxi Univ, Res Ctr Environm Sci & Engn, Taiyuan 030006, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiushi,Dong, Chuan,Ren, Guixing. Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(4):1138-1144.
APA	Yang, Xiushi,Dong, Chuan,&Ren, Guixing.(2011).Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(4),1138-1144.
MLA	Yang, Xiushi,et al."Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.4(2011):1138-1144.