Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2

doi:10.1016/j.jff.2013.10.020

	Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2
	Yang, Nan 1; Li, Yuk Man 1; Zhang, Kunsheng 2; Jiao, Rui 3; Ma, Ka Ying 1; Zhang, Rui 4; Ren, Guixing 5; Chen, Zhen-Yu 1
刊名	JOURNAL OF FUNCTIONAL FOODS
	2014
卷号	6 页码:311-318
关键词	ACAT2 Hypocholesterolemia NPC1L1 Rice flour Tartary buckwheat flour Wheat flour
ISSN号	1756-4646
DOI	10.1016/j.jff.2013.10.020
通讯作者	Yang, Nan
英文摘要	Interest in Tartary buckwheat as a cholesterol-lowering functional food is increasing. The present study was to (i) investigate the relative hypocholesterolemic activity of Tartary buckwheat flour compared with that of wheat and rice flour; and (ii) study the interaction of these three flours with gene expression of sterol transporters and proteins involved in cholesterol absorption. Thirty-six male hamsters were divided into four groups fed either the control or one of three experimental diets containing 24% respective flour, for a period of 6 weeks. Results showed that Tartary buckwheat flour but no wheat and rice flours reduced plasma total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL) as well as hepatic cholesterol concentrations. Compared with that of wheat and rice flours, supplementation of Tartary buckwheat flour into diet led to greater neutral sterol excretion and lesser mRNA of intestinal Niemann-Pick C1 Like 1 (NPC1L1) and acyl-CoA: cholesterol acyltransferase 2 (ACAT2). It was therefore concluded that Tartary buckwheat flour was hypocholesterolemic via inhibition of cholesterol absorption, most likely mediated by down-regulation of intestinal NPC1L1 and ACAT2. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题	Food Science & Technology ; FOOD SCIENCE & TECHNOLOGY
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000331423000031
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/4967]
专题	作物科学研究所_种质资源保存与研究中心
作者单位	1.Chinese Univ Hong Kong, Sch Life Sci, Food & Nutr Sci Programme, Shatin, Hong Kong, Peoples R China 2.Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Tianjin, Peoples R China 3.Jinan Univ, Coll Sci & Engn, Guangzhou, Guangdong, Peoples R China 4.China Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun, Peoples R China 5.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Yang, Nan,Li, Yuk Man,Zhang, Kunsheng,et al. Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2[J]. JOURNAL OF FUNCTIONAL FOODS,2014,6:311-318.
APA	Yang, Nan.,Li, Yuk Man.,Zhang, Kunsheng.,Jiao, Rui.,Ma, Ka Ying.,...&Chen, Zhen-Yu.(2014).Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2.JOURNAL OF FUNCTIONAL FOODS,6,311-318.
MLA	Yang, Nan,et al."Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2".JOURNAL OF FUNCTIONAL FOODS 6(2014):311-318.