Anti-Inflammatory Activity of Saponins from Quinoa ( Chenopodium quinoa Willd.) Seeds in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages Cells

doi:10.1111/1750-3841.12425

	Anti-Inflammatory Activity of Saponins from Quinoa ( Chenopodium quinoa Willd.) Seeds in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages Cells
	Yao, Yang 1; Yang, Xiushi 1,2; Shi, Zhenxing 1; Ren, Guixing 1
刊名	JOURNAL OF FOOD SCIENCE
	2014
卷号	79 期号:5 页码:H1018-H1023
关键词	anti-inflammation LPS quinoa saponins
ISSN号	0022-1147
DOI	10.1111/1750-3841.12425
通讯作者	Yao, Yang
英文摘要	Quinoa (Chenopodium quinoa Willd.) is a pseudocereal from South Americas that has received increased interest around the world because it is a good source of different nutrients and rich in saponins. However, the saponins in quinoa seeds planted in China were poorly known. We obtained 4 quinoa saponin fractions, Q30, Q50, Q70, and Q90, and 11 saponins were determined by HPLC-MS. Q50 possessed 8 individual saponins and had the highest content of saponins. We further evaluated the anti-inflammatory activity on RAW 264.7 murine macrophage cells of the 4 fractions. The 4 fractions not only dose-dependently decreased the production of inflammatory mediators NO but also inhibited the release of inflammatory cytokines including tumor necrosis factor- and interleukin-6 in lipopolysaccharide-induced RAW264.7 cells. These results suggest that quinoa saponins may be used as functional food components for prevention and treatment of inflammation.Practical ApplicationOur findings demonstrate that saponins from the quinoa have the potential to anti-inflammation by suppressing the release of inflammatory cytokines.
学科主题	Food Science & Technology ; FOOD SCIENCE & TECHNOLOGY
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000335491600034
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/4888]
专题	作物科学研究所_种质资源保存与研究中心
作者单位	1.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China 2.Shanxi Univ, Res Ctr Environm Sci & Engn, Taiyuan 030006, Peoples R China
推荐引用方式 GB/T 7714	Yao, Yang,Yang, Xiushi,Shi, Zhenxing,et al. Anti-Inflammatory Activity of Saponins from Quinoa ( Chenopodium quinoa Willd.) Seeds in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages Cells[J]. JOURNAL OF FOOD SCIENCE,2014,79(5):H1018-H1023.
APA	Yao, Yang,Yang, Xiushi,Shi, Zhenxing,&Ren, Guixing.(2014).Anti-Inflammatory Activity of Saponins from Quinoa ( Chenopodium quinoa Willd.) Seeds in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages Cells.JOURNAL OF FOOD SCIENCE,79(5),H1018-H1023.
MLA	Yao, Yang,et al."Anti-Inflammatory Activity of Saponins from Quinoa ( Chenopodium quinoa Willd.) Seeds in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages Cells".JOURNAL OF FOOD SCIENCE 79.5(2014):H1018-H1023.