A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease

doi:10.1186/s13195-017-0267-5

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	A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease
	Wang, Shao-wei 1; Liu, Dong-qun 1; Zhang, Ling-xiao 1; Ji, Mei 1; Zhang, Yang-xin 1,2; Dong, Quan-xiu 1; Liu, Shu-ying 1,3; Xie, Xi-xiu 1; Liu, Rui-tian 1
刊名	ALZHEIMERS RESEARCH & THERAPY
	2017-06-07
卷号	9
关键词	Alzheimer's Disease Beta-amyloid Oligomer Mimotope Saccharomyces Cerevisiae Vaccine
ISSN号	1758-9193
DOI	10.1186/s13195-017-0267-5
文献子类	Article
英文摘要	Background: beta-Amyloid peptide (A beta) oligomers are initial factors used to induce Alzheimer's disease (AD) development, and A beta monomers have normal physiological function. The antibodies or vaccines against A beta monomers have serious problems, such as side effects and low curative effects. Therefore, it is essential to specifically target A beta oligomers rather than monomers for the treatment of AD.
WOS关键词	Amyloid-beta ; Vanutide Cridificar ; Qs-21 Adjuvant ; Phase-3 Trials ; 2-phase 2 ; Immunotherapy ; Autoantibodies ; Immunization ; Mechanism ; Peptide
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000403027200001
资助机构	National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2012ZX09103301-001 ; 31471720 ; 2014ZX09102045-006) ; 31101335)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/22798]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China 3.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shao-wei,Liu, Dong-qun,Zhang, Ling-xiao,et al. A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease[J]. ALZHEIMERS RESEARCH & THERAPY,2017,9.
APA	Wang, Shao-wei.,Liu, Dong-qun.,Zhang, Ling-xiao.,Ji, Mei.,Zhang, Yang-xin.,...&Liu, Rui-tian.(2017).A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease.ALZHEIMERS RESEARCH & THERAPY,9.
MLA	Wang, Shao-wei,et al."A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease".ALZHEIMERS RESEARCH & THERAPY 9(2017).