Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 省部共建新疆特有药用资源利用重点实验室

	Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity
	Gao, J (Gao, Jie); Aisa, HA (Aisa, Haji A.)
刊名	JOURNAL OF NATURAL PRODUCTS
	2017
卷号	80 期号:6 页码:1767-1775
通讯作者	Aisa, HA
英文摘要	Ten new terpenoids, including five-diterpenoids (1-5); three nortriterpenoids (6-8), and two triterpenoids (9, 10), and 15 known terpenoids (11-25) were isolated from an acetone extract of Euphorbia soongarica. Sooneuphoramine (1) is the first example of a euphoractine B-type diterpenoid alkaloid, while sooneuphanones A-C (6-8) are rare nortriterpenoids from the Euphorbia genus. The isolated terpenoids were tested for their cytotoxicity and Multidrug resistance (MDR) reversal activity, 10 of which showed moderate cytotoxicity against the KB arid KBv200 cell lines, while 11 compounds exhibited PT-gp modulating potential. The triterpenoid sooneuphanone D (9) possessed a remarkable MDR reversal activity much higher than the positive control, verapamil.
收录类别	SCI
WOS记录号	WOS:000404322100008
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/4819]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
作者单位	1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Gao, J ,Aisa, HA . Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1767-1775.
APA	Gao, J ,&Aisa, HA .(2017).Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.JOURNAL OF NATURAL PRODUCTS,80(6),1767-1775.
MLA	Gao, J ,et al."Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity".JOURNAL OF NATURAL PRODUCTS 80.6(2017):1767-1775.