Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application

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	Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application
	Li, Mei ; Yang, Xuan ; Wang, Weidan ; Zhang, Yu ; Wan, Peng ; Yang, Ke ; Han, Yong
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2017-04-01
卷号	73 页码:347-356
ISSN号	0928-4931
通讯作者	Han, Y (reprint author), Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China. ; Wan, P (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
中文摘要	Regeneration of bone defects is a clinical challenge that usually necessitates bone grafting materials. Limited bone supply and donor site morbidity limited the application of autografting, and improved biomaterials are needed to match the performance of autografts. Osteoinductive materials would be the perfect candidates for achieving this task. Strontium (Sr) is known to encourage bone formation and also prevent osteoporosis. Such twin requirements have motivated researchers to develop Sr-substituted biomaterials for orthopedic applications. The present study demonstrated a new concept of developing biodegradable and hollow three-dimensional magnesium strontium (Mg Sr) devices for grafting with their clinical demands. The microstructure and performance of Mg Sr devices, in vitro degradation and biological properties including in vitro cytocompatibility and osteoinductivity were investigated. The results showed that our Mg Sr devices exhibited good cytocompatibility and osteogenic effect To further investigate the underlying mechanisms, RT-PCR and Western Blotting assays were taken to analyze the expression level of osteogenesis-related genes and proteins, respectively. The results showed that our Mg Sr devices could both up-regulate the genes and proteins expression of the transcription factors of Runt-related transcription factor 2 (RUNX2) and Osterix (OSX), as well as alkaline phosphatase (ALP), Osteopontin (OPN), Collagen I (COL I) and Osteocalcin (OCN) significantly. Taken together, our innovation presented in this work demonstrated that the hollow three-dimensional Mg Sr substitutes had excellent biocompatibility and osteogenesis and could be potential candidates for bone grafting for future orthopedic applications. (C) 2016 Elsevier B.V. All rights reserved.
学科主题	Materials Science, Biomaterials
收录类别	SCI
资助信息	National Natural Science Foundation of China [81501859, 81601884, 51631007, 51371137]; Natural Stience Foundation of Guangdong Province, China [2015A030313607]; Guangdong Provincial Science and Technology Project [2014A020215025]
语种	英语
公开日期	2017-08-17
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/78216]
专题	金属研究所_中国科学院金属研究所
推荐引用方式 GB/T 7714	Li, Mei,Yang, Xuan,Wang, Weidan,et al. Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,73:347-356.
APA	Li, Mei.,Yang, Xuan.,Wang, Weidan.,Zhang, Yu.,Wan, Peng.,...&Han, Yong.(2017).Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,73,347-356.
MLA	Li, Mei,et al."Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 73(2017):347-356.