Bioinspired Engineering of Poly(ethylene glycol) Hydrogels and Natural Protein Fibers for Layered Heart Valve Constructs

CORC > 金属研究所 > 中国科学院金属研究所

	Bioinspired Engineering of Poly(ethylene glycol) Hydrogels and Natural Protein Fibers for Layered Heart Valve Constructs
	Li, Qian ; Bai, Yun ; Jin, Tao ; Wang, Shuo ; Cui, Wei ; Stanciulescu, Ilinca ; Yang, Rui ; Nie, Hemin ; Wang, Linshan ; Zhang, Xing
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-05-17
卷号	9 期号:19 页码:16524-16535
关键词	heart valves poly(ethylene glycol) hydrogels protein fibers layered structures calcification enzymatic degradation
ISSN号	1944-8244
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China. ; Wang, LS (reprint author), Northeastern Univ, Dept Chem, Shenyang 110004, Liaoning, Peoples R China. ; Nie, HM (reprint author), Hunan Univ, Coll Life Sci, Inst Bionanotechnol & Tissue Engn, Changsha 410082, Hunan, Peoples R China. ; Zhang, X (reprint author), Univ Sci & Technol China, Sch Mat Sci, Hefei 230026, Anhui, Peoples R China.
中文摘要	Layered constructs from poly(ethylene glycol) (PEG) hydrogels and chicken eggshell membranes (ESMs) are fabricated, which can be further cross-linked by glutaraldehyde (GA) to form GA-PEG-ESM composites. Our results indicate that ESMs composed of protein fibrous networks show elastic moduli similar to 3.3-5.0 MPa and elongation percentages similar to 47-56%, close to human heart valve leaflets. Finite element simulations reveal obvious stress concentration on a partial number of fibers in the GA-cross-linked ESM (GA-ESM) samples, which can be alleviated by efficient stress distribution among multiple layers of ESMs embedded in PEG hydrogels. Moreover, the polymeric networks of PEG hydrogels can prevent mineral deposition and enzyme degradation of protein fibers from incorporated ESMs. The fibrous structures of ESMs retain in the GA-PEG-ESM samples after subcutaneous implantation for 4 weeks, while those from ESM and GA-ESM samples show early degradation to certain extent, suggesting the prevention of enzymatic degradation of protein fibers by the polymeric network of PEG hydrogels in vivo. Thus, these GA-PEG-ESM layered constructs show heterogenic structures and mechanical properties comparable to heart valve leaflets, as well as improved functions to prevent progressive calcification and enzymatic degeneration, which are likely used for artificial heart valves.
学科主题	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
收录类别	SCI
资助信息	National Natural Science Foundation of China [31300788, 31670981]; Chinese Academy of Sciences
语种	英语
公开日期	2017-08-17
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/78131]
专题	金属研究所_中国科学院金属研究所
推荐引用方式 GB/T 7714	Li, Qian,Bai, Yun,Jin, Tao,et al. Bioinspired Engineering of Poly(ethylene glycol) Hydrogels and Natural Protein Fibers for Layered Heart Valve Constructs[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(19):16524-16535.
APA	Li, Qian.,Bai, Yun.,Jin, Tao.,Wang, Shuo.,Cui, Wei.,...&Zhang, Xing.(2017).Bioinspired Engineering of Poly(ethylene glycol) Hydrogels and Natural Protein Fibers for Layered Heart Valve Constructs.ACS APPLIED MATERIALS & INTERFACES,9(19),16524-16535.
MLA	Li, Qian,et al."Bioinspired Engineering of Poly(ethylene glycol) Hydrogels and Natural Protein Fibers for Layered Heart Valve Constructs".ACS APPLIED MATERIALS & INTERFACES 9.19(2017):16524-16535.