Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway
	Zheng, Shan-Qing 1,2; Huang, Xiao-Bing 1,2; Xing, Ti-Kun 1,2; Ding, Ai-Jun 1,2; Wu, Gui-Sheng1 ; Luo, Huai-Rong1
刊名	JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
	2017-04-01
卷号	72 期号:4 页码:464-472
关键词	Chlorogenic acid Caenorhabditis elegans DAF-16/FOXO Longevity Stress resistance
英文摘要	Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease. CGA is also present in many traditional Chinese medicines. However, the mechanism of these effects was vague. The aging signaling pathways were conservative from yeast and worms to mammals. So, we tested if CGA had an effect on aging in Caenorhabditis elegans. We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance. We conducted genetic analysis with a series of worm mutants and found that CGA could extend the lifespan of the mutants of eat-2, glp-1, and isp-1, but not of daf-2, pdk-1, akt-1, akt-2, sgk-1, and clk-1. CGA could activate the FOXO transcription factors DAF-16, HSF-1, SKN-1, and HIF-1, but not SIR-2.1. Taken together, CGA might extend the lifespan of C. elegans mainly via DAF-16 in insulin/IGF-1 signaling pathway.
类目[WOS]	Geriatrics & Gerontology ; Gerontology
研究领域[WOS]	Geriatrics & Gerontology
关键词[WOS]	PROTEIN-KINASE-B ; HEAT-SHOCK FACTOR ; C-ELEGANS ; OXIDATIVE-STRESS ; DIETARY RESTRICTION ; ELECTRON-TRANSPORT ; FAT-METABOLISM ; RISK-FACTOR ; IN-VITRO ; LONGEVITY
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000402110100002
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/51242]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Shan-Qing,Huang, Xiao-Bing,Xing, Ti-Kun,et al. Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2017,72(4):464-472.
APA	Zheng, Shan-Qing,Huang, Xiao-Bing,Xing, Ti-Kun,Ding, Ai-Jun,Wu, Gui-Sheng,&Luo, Huai-Rong.(2017).Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,72(4),464-472.
MLA	Zheng, Shan-Qing,et al."Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 72.4(2017):464-472.