Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice
	Zhu, Limeng 1,2; Qin, Song1 ; Zhai, Shixiang 1; Gao, Yonglin 3; Li, Lili1
刊名	FEMS MICROBIOLOGY LETTERS
	2017-05-01
卷号	364 期号:10
关键词	butyrate-producing bacteria degrees of polymerization fructo-oligosaccharides intestinal microbiota inulin metagenomics
ISSN号	0378-1097
英文摘要	The study aimed to analyze the global influences of dietary inulin with different degrees of polymerization (DP) on intestinal microbial communities. Six-week-old male C57BL/6J mice were treated with fructo-oligosaccharides and inulin for 6 weeks. Fecal samples were obtained at time point 0 and 6th week. 16S rRNA sequence analysis was used to measure intestinal microbiota performed on the Illumina MiSeq platform. Influences of dietary inulin on intestinal microbiota were more complex effects than bifidogenic effects, relative abundance of butyrate-producing bacteria increased after interventions. Akkermansia muciniphila, belonging to mucin-degrading species, became a dominant species in Verrucomicrobia phylum after treatment with fructo-oligosaccharides and inulin. Modulation effects of intestinal microbiota were positively correlated with DP. Lower DP interventions exhibited better effects than higher DP treatment on stimulation of probiotics. We hypothesized that Akkermansia muciniphila played an important role on maintaining balance between mucin and short chain fatty acids.
研究领域[WOS]	Microbiology
关键词[WOS]	CHAIN FATTY-ACID ; BUTYRATE-PRODUCING BACTERIA ; GUT MICROBIOTA ; AKKERMANSIA-MUCINIPHILA ; HEALTH ; STIMULATION ; DIVERSITY ; DIETARY ; COLON ; RATS
收录类别	SCI
语种	英语
WOS记录号	WOS:000404534500010
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/22546]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Costal Zone Res, 17 Chunhui Rd, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yantai Univ, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Limeng,Qin, Song,Zhai, Shixiang,et al. Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice[J]. FEMS MICROBIOLOGY LETTERS,2017,364(10).
APA	Zhu, Limeng,Qin, Song,Zhai, Shixiang,Gao, Yonglin,&Li, Lili.(2017).Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice.FEMS MICROBIOLOGY LETTERS,364(10).
MLA	Zhu, Limeng,et al."Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice".FEMS MICROBIOLOGY LETTERS 364.10(2017).