TRAF6 is a critical factor in fish immune response to virus infection

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	TRAF6 is a critical factor in fish immune response to virus infection
	Wei, JG; Zang, SQ; Xu, M; Zheng, QJ; Chen, XL; Qin, QW
刊名	FISH & SHELLFISH IMMUNOLOGY
	2017
卷号	60 页码:6-12
关键词	Epinephelus tauvina TRAF6 Interferon SGIV Apoptosis
通讯作者	qinqw@scsio.ac.cn
中文摘要	Tumor necrosis factor receptor-associated factor 6 (TRAF6) is one of the key adaptor molecule in Toll-like receptor signal transduction that triggers downstream cascades involved in innate immunity. In our previous study, the molecular characteristics of EtTRAF6 (TRAF6 from Epinephelus tauvina), the tissue distributions, expression patterns after challenging with bacterial and viral pathogens were investigated. Here we identified EtTRAF6 as an important regulator of virus-triggered signaling pathway. Over expression of EtTRAF6-ORF and truncated forms of EtTRAF6, including EtTRAF6-C (delete the MATH domain), EtTRAF6-N (delete the RING domain) and EtTRAF6-MATH, inhibited IFN-beta activity strongly in grouper spleen (GS) cells. Overexpression of EtTRAF6 repressed virus-induced production of type I IFNs. When EtTRAF6 cotransfected with EcIRF3 or EcIRF7, EtTRAF6 inhibited IRF-induced activation of IFN-beta. Over-expressed EtTRAF6 inhibited" the transcription of SGIV genes significantly in GS cells. Although TRAF6 has a role in apoptosis regulation, it is not known if EtTRAF6 has any role in apoptosis regulation. Strikingly, when over-expressed in fathead minnow (FHM) cells, EtTRAF6 protected them from cell death induced by SGIV. Therefore, these results suggest that TRAF6 may play a critical role in their response to SGIV infection, through regulation of a cell death pathway that is common to fish and humans. (C) 2016 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16214]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Wei, JG,Zang, SQ,Xu, M,et al. TRAF6 is a critical factor in fish immune response to virus infection[J]. FISH & SHELLFISH IMMUNOLOGY,2017,60:6-12.
APA	Wei, JG,Zang, SQ,Xu, M,Zheng, QJ,Chen, XL,&Qin, QW.(2017).TRAF6 is a critical factor in fish immune response to virus infection.FISH & SHELLFISH IMMUNOLOGY,60,6-12.
MLA	Wei, JG,et al."TRAF6 is a critical factor in fish immune response to virus infection".FISH & SHELLFISH IMMUNOLOGY 60(2017):6-12.