IN THE PURSUIT OF A BETTER SWEETENER

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	IN THE PURSUIT OF A BETTER SWEETENER
	Ceng GZ(曾广植) ; Chen JT(陈金泰) ; He HZ(何华中) ; Wang ZQ(王肇卿) ; Yan JS(严家生)
刊名	J. Agric. Food Chem.
	1991
卷号	39 期号:4 页码:782-785
ISSN号	0021-8561
其他题名	IN THE PURSUIT OF A BETTER SWEETENER
通讯作者	曾广植
英文摘要	Dipeptide sweeteners of the AspNHCH(R1)COR type, where R1 = H, Me, CH2OH, and CO2Me and R = OR2 or NHR2 with R2 less-than-or-equal-to C10 atoms, i.e., alkyl, aryl, heterocyclic, bi- or tricyclic group, were synthesized to remedy the well-known shortcomings of aspartame. For the design of these sweeteners, the classic theory of Cohn-Oertly-Myers, Ariyoshi's rule of steric size difference, Newman's rule of H-6 number as well as our C-9 rule and a model of induced fitting of multiple-point attachment with the sweet receptor were employed. On the basis of our results as well as those of others, qualitative and semi-quantitative structure-activity relationships were discussed according to the current concepts of polar-steric-hydrophobic factor analyses for the pursuit of an ideal high sweetness potency dipeptide sweetener. Compounds of high sweetness potency prepared in this work are all of high stabilities and indifferent to microorganisms or any known genetic diseases.
学科主题	有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/jf00004a033
语种	英语
公开日期	2013-03-11
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/23994]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Ceng GZ,Chen JT,He HZ,et al. IN THE PURSUIT OF A BETTER SWEETENER[J]. J. Agric. Food Chem.,1991,39(4):782-785.
APA	曾广植,陈金泰,何华中,王肇卿,&严家生.(1991).IN THE PURSUIT OF A BETTER SWEETENER.J. Agric. Food Chem.,39(4),782-785.
MLA	曾广植,et al."IN THE PURSUIT OF A BETTER SWEETENER".J. Agric. Food Chem. 39.4(1991):782-785.