The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design

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	The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design
	Li P(李鹏) ; Xu JC(徐杰诚)
刊名	J. Pept. Res.
	2001
卷号	58 期号:2 页码:129-139
ISSN号	1397-002X
其他题名	根据合理分子设计的氧正离子型高效缩合剂的发展
通讯作者	徐杰诚
英文摘要	Novel and highly efficient immonium-, pyridinium-and thiazolium-type peptide coupling reagents, such as BOMI, BDMP, BPMP,BEP,FEP,BEPH,FEPH and BEMT, were developed by rational modifying of the molecular structures of commonly used uronium-type reagents. The high efficiency of these onium salts has been evaluated and proven by model reaction tests and the successful synthesis of various oligopeptides and biologically active peptides, both in solution and in the solid-phase, for example Leu-enkephalin, the pentapeptide moiety of Dolastatin 15 and the immunosuppressive undecapeptide cyclosporin O. Based upon these results, the relationship between the molecular structure and the capability of oniumtype peptide coupling reagents was studied. A preliminary guideline for the molecular design of onium-type coupling reagents was developed.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1034/j.1399-3011.2001.00867.x
语种	英语
WOS记录号	WOS:000170471700004
公开日期	2013-03-04
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22644]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Li P,Xu JC. The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design[J]. J. Pept. Res.,2001,58(2):129-139.
APA	李鹏,&徐杰诚.(2001).The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design.J. Pept. Res.,58(2),129-139.
MLA	李鹏,et al."The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design".J. Pept. Res. 58.2(2001):129-139.