Identification of two herbal compounds with potential cholesterol-lowering activity

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	Identification of two herbal compounds with potential cholesterol-lowering activity
	Zhang YL(张宜林) ; Zhang HQ(张海青) ; Hua SN(华时能) ; Ma LH(马梁辉) ; Chen C(陈聪) ; Liu XY(刘晓玉) ; Jiang LQ(蒋利群) ; Yang HM(杨焕明) ; Zhang PC(张培成) ; Yu DQ(于德全) ; Guo YL(郭寅龙) ; Tan XH(谭学海) ; Liu JF(刘建峰)
刊名	Biochem. Pharmacol.
	2007
卷号	74 期号:6 页码:940-947
ISSN号	0006-2952
其他题名	两种具有潜在降胆固醇活性的中药化合物的鉴定研究
通讯作者	谭学海 ; 刘建峰
英文摘要	Low-density lipoprotein receptor (LDLR) plays a pivotal role in the control of plasma LDL-cholesterol level. This occurs predominantly at the transcriptional level through two gene regulation elements, named SRE: sterol- responsive element and SIRE: sterol-independent responsive element. We have developed a high-throughput screening using LDLR promoter activation -based assay to search for cholesterol-lowering compounds from a Chinese herb-based natural compound library. With this approach, we identified two compounds, named Daphnetoxin and Gniditrin, from Chinese herb Daphne giraldii Nitsche, which could activate LDLR promoter. Characterization of these compounds showed that they increased the level of LDLR mRNA and consequently up-regulate LDLR expression. The structures of these compounds are different from well-known LDLR promoter activating compounds such as GW707. The results suggested that these herbal compounds could represent good candidates for development of new classes of cholesterol-lowering drugs. (C) 2007 Elsevier Inc. All rights reserved.
学科主题	分析化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.bcp.2007.06.020
语种	英语
WOS记录号	WOS:000249323800015
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/19952]
专题	上海有机化学研究所_分析化学研究室
推荐引用方式 GB/T 7714	Zhang YL,Zhang HQ,Hua SN,et al. Identification of two herbal compounds with potential cholesterol-lowering activity[J]. Biochem. Pharmacol.,2007,74(6):940-947.
APA	张宜林.,张海青.,华时能.,马梁辉.,陈聪.,...&刘建峰.(2007).Identification of two herbal compounds with potential cholesterol-lowering activity.Biochem. Pharmacol.,74(6),940-947.
MLA	张宜林,et al."Identification of two herbal compounds with potential cholesterol-lowering activity".Biochem. Pharmacol. 74.6(2007):940-947.