Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment

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	Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment
	Wei JC(韦佳辰); Song F(宋凡)
刊名	INTERNATIONAL JOURNAL OF MODERN PHYSICS B
	2017-01-30
卷号	31 期号:3
关键词	Globular protein association equilibria short-range attraction macromolecular crowding
ISSN号	0217-9792
中文摘要	Based on a very simple coarse-grained colloidal model here we implement an effective hard-sphere theory and numerical simulation to capture the general features of the association equilibria for globular proteins in crowded environment. We measure the activity coefficient i.e. the deviation from ideal behavior of protein solution and the crowding factor i.e. the contribution of crowders to the association equilibria for proteins in macromolecular crowding. The results show that the association balance in macro molecular crowding depends sensitively on the magnitude of protein-crowder attraction and the relative size of reactant to crowding agent. Since our coarse-grained model is irrelevant to the microscopic details of the molecules it can be applied to the control of the association equilibria of many globular proteins such as bovine serum albumin crystallin and lysozyme.
类目[WOS]	Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical
研究领域[WOS]	Physics
关键词[WOS]	BOVINE SERUM-ALBUMIN ; LIGHT-SCATTERING ; MODEL ; DEPENDENCE ; REPULSION ; SPHERES
收录类别	SCI
语种	英语
WOS记录号	WOS:000395314300007
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/60591]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Wei JC,Song F. Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2017,31(3).
APA	韦佳辰,&宋凡.(2017).Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,31(3).
MLA	韦佳辰,et al."Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 31.3(2017).