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题名靶向性凝血蛋白tTF-EG3287选择性诱发小鼠原位肝癌血管栓塞; Selective Thrombosis in Orthotopic Tumor Model of Hepatocellular Carcinoma in Mice Induced by Targeted Coagulation Protein tTF-EG3287
作者王显江
答辩日期2017-03-28 ; 2015-05-13
导师颜江华
关键词TACE 血管靶向 凝血蛋白 原位肝癌 血管栓塞 TACE Vascular targeting Coagulation protein Orthotopic hepatocellular carcinoma Thromboembolism
英文摘要肝癌是最常见的恶性肿瘤之一,具有发病率高、复发率高、预后差的特点,经肝动脉化疗栓塞(transarterialchemoembolization,TACE)是目前公认的肝癌非手术治疗的首选方法。目前临床上常用的栓塞材料各有优缺点,在临床应用中如何对症使用尚无统一标准,而且TACE治疗能否提高肝癌病人的生存率,仍然存在争议,TACE治疗存在种种缺陷如栓塞不全、缺乏靶向性、毒副作用大、栓塞剂稳定性与可控性差和伴随血管内皮生长因子升高等。因此,发展新型高效的、具有靶向性、可控性强、无毒的肿瘤血管栓塞剂依然是目前肝癌临床治疗亟待解决的重大问题。 针对以上问题,我们计划采用一种基于靶向性凝血蛋白的选择...; Hepatocellular carcinoma, one of the most commonly occurring cancer, is responsible for significant mortality worldwide, with its increasing morbidity, high recurrence and poor prognosis. Transarterial chemoembolization (TACE) is recommended as the current standard care for patients with intermediate-stage hepatocellular carcinoma. However, considering the advantages and disadvantages of conventio...; 学位:医学硕士; 院系专业:医学院_肿瘤学; 学号:24520121153240
语种zh_CN
出处http://210.34.4.13:8080/lunwen/detail.asp?serial=49506
内容类型学位论文
源URL[http://dspace.xmu.edu.cn/handle/2288/135271]  
专题医学院-学位论文
推荐引用方式
GB/T 7714
王显江. 靶向性凝血蛋白tTF-EG3287选择性诱发小鼠原位肝癌血管栓塞, Selective Thrombosis in Orthotopic Tumor Model of Hepatocellular Carcinoma in Mice Induced by Targeted Coagulation Protein tTF-EG3287[D]. 2017, 2015.
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