题名 | 泛素化抑制剂Thalidomide和PYR-41对树突状细胞抗原交叉提呈的作用研究; The effects of ubiquitination inhibitors Thalidomide and PYR-41 on cross-presentation of dendritic cells |
作者 | 游翔 |
答辩日期 | 2017-03-27 ; 2016-12-07 |
导师 | 高丰光 |
关键词 | 树突状细胞 泛素化 交叉提呈 Dendritic cells Ubiquitination Cross-presentation |
英文摘要 | 树突状细胞(Dendriticcells,DCs)是机体最为重要的抗原提呈细胞(Antigenpresentingcell,APC)。DCs对抗原的交叉提呈是指外源性抗原被DCs摄取和加工后,与MHCI类分子结合形成CD8+特异性抗原肽-MHCI类分子复合物的过程,可使T细胞分化为CD8+特异性细胞毒T细胞(CytotoxicTlymphocyte,CTL)。甘露糖受体(Mannosereceptor,MR)是DCs表面重要的的模式识别受体(Patternrecognitionreceptor,PRR),DCs对可溶性抗原的交叉提呈依赖于MR介导的抗原内吞及MR的泛素化修饰。但迄今为止,泛素化...; Dendritic cells (DCs) are the most important antigen presenting cells (APCs) in adaptive immune response. Cross-presentation refers to the process that internalized exogenous antigens was processed and combined with MHC class I to form the peptide-MHC class I complex, which contribute to T cell activation and CTL differention. Mannose receptor (MR) is a critical pathogen recognition receptor in DC...; 学位:理学硕士; 院系专业:医学院_微生物学; 学号:24520131153450 |
语种 | zh_CN |
出处 | http://210.34.4.13:8080/lunwen/detail.asp?serial=59254 |
内容类型 | 学位论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/135255] |
专题 | 医学院-学位论文 |
推荐引用方式 GB/T 7714 | 游翔. 泛素化抑制剂Thalidomide和PYR-41对树突状细胞抗原交叉提呈的作用研究, The effects of ubiquitination inhibitors Thalidomide and PYR-41 on cross-presentation of dendritic cells[D]. 2017, 2016. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论