| 幽门螺杆菌根除治疗效果分析; Effect Analysis of Helicobacter Pylori Eradication | |
| 柯金珍 ; 郑建玮 ; 谢黎崖 ; 陈丰庆 ; 洪俩和 | |
| 2012 | |
| 关键词 | 螺杆菌 幽门 治疗学 质子泵抑制剂 抗菌药 Helicobacter pylori Therapeutics Proton pump inhibitors Anti-bacterial agents |
| 英文摘要 | 目的从幽门螺杆菌(HElICObACTEr PylOrI,H.PylOrI)根治的疗效角度,探讨影响H.PylOrI治疗的可能因素,以期为临床合理用药提供依据。方法对本院2010年1月—2011年9月经胃镜尿素酶检查和(或)13C-呼气试验检测H.PylOrI阳性患者的治疗情况进行随访,收集H.PylOrI治疗结果并进行统计、分析。结果患者资料完整者共502例,H.PylOrI总体根除率为60.76%,其中男性根除率为66.67%(164/246),女性根除率为55.08%(141/256),不同性别H.PylOrI根除率比较,差异有统计学意义(χ2=7.066,P<0.05)。本研究分7个年龄段(未满18岁者未纳入年龄段统计),成年人各年龄段总体H.PylOrI根除率比较,差异无统计学意义(P>0.05)。本研究筛选出9种不同的H.PylOrI根治方案,其中以质子泵抑制剂(PPI)+铋剂(b)+克拉霉素(C)+左氧氟沙星(l)方案H.PylOrI根除率最高(为80.49%),PPI+b+l+替硝唑(TIn)的H.PylOrI根除率最低(为50.00%),两种方案H.PylOrI根除率比较,差异有统计学意义(χ2=7.570,P<0.05);含TIn的H.PylOrI根除方案,除PPI+阿莫西林(A)+TIn方案外,H.PylOrI根除率偏低;PPI+阿莫西林双氯西林(ACl)+TIn方案H.PylOrI根除率为55.10%,与PPI+b+ACl+TIn方案的60.78%比较,差异无统计学意义(χ2=0.331,P>0.05)。7 d疗程方案者占63.75%,H.PylOrI根除率为63.44%,较其他疗程高,各疗程间H.PylOrI根除率比较,差异无统计学意义(χ2=3.294,P>0.05)。埃索美拉唑(ESO)与奥美拉唑(OME)方案H.PylOrI根除率比较,差异有统计学意义(χ2=7.839,P=0.005,检验水准调整值为0.008)。结论 H.PylOrI根除率与性别、治疗方案、PPI有关,与年龄、疗程无关。; Objective To explore factors that affect the outcomes of Helicobacter pylori(H.pylori) eradication.Methods A total of 502 patients who were confirmed to be with H.pylori infection by Gastroscope urease and/or 13C-UBT in our hospital between January 2010 and September 2011 were enrolled in this study.The relevant data were collected and analyzed.Results The total eradication rate was 60.76%,in which the eradication rate was 66.67%(164/246)in males and 55.08%(141/256)in females(χ2=7.066,P<0.05).The eradication rates showed no significant difference among different age groups(P>0.05).Among the 9 therapeutic regimens,PPI+B+C+L achieved the highest eradication rate(80.49%),whereas PPI+B+L+Tin had the lowest one(50.00%)(χ2=7.570,P<0.05).The Tin-based regimens had low eradication rates(except PPI+A+Tin).The eradication rate of PPI+B+ACL+Tin was 60.78%,but it was not statistically different from PPI+ACL+Tin(55.10%)(χ2=0.331,P>0.05).About 63.75% of the patients applied the 7-day regimen,and the the eradication rate was 63.44%,which was higher than other regimens.The eradication rates showed no statistical difference among different treatment cycles(χ2=3.294,P>0.05).The esomeprazole group and omeprazole group had significantly different H.pylori eradication rates(χ2=7.839,P=0.005).Conclusion The H.pylori eradication rate is related to gender,treatment scheme,and proton-pump inhibitors,but not to age and treatment cycle. |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/123396]  |
| 专题 | 药学院－已发表论文 |
| 推荐引用方式 GB/T 7714 | 柯金珍,郑建玮,谢黎崖,等. 幽门螺杆菌根除治疗效果分析, Effect Analysis of Helicobacter Pylori Eradication[J],2012. |
| APA | 柯金珍,郑建玮,谢黎崖,陈丰庆,&洪俩和.(2012).幽门螺杆菌根除治疗效果分析.. |
| MLA | 柯金珍,et al."幽门螺杆菌根除治疗效果分析".(2012). |
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