Angiomotin'g YAP into the Nucleus for Cell Proliferation and Cancer Development

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	Angiomotin'g YAP into the Nucleus for Cell Proliferation and Cancer Development
	Hong, Wanjin ; Hong WJ(洪万进)
刊名	http://dx.doi.org/10.1126/scisignal.2004573
	2013
关键词	HIPPO PATHWAY PROTEIN GTPASE
英文摘要	The Hippo pathway regulates cell proliferation and apoptosis during development, tissue regeneration, and carcinogenesis. Nuclear translocation of the transcription factors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) and their subsequent interaction with TEA domain (TEAD) transcriptional factors program pro-proliferative and antiapoptotic transcription. Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by preventing their nuclear translocation. In this issue of Science Signaling, Yi et al. show that Amot may also promote nuclear translocation of YAP and act as a transcriptional cofactor of the YAP-TEAD complex to facilitate proliferation of biliary epithelial cells and cancer development of the liver either in response to tissue injury or in the absence of the tumor suppressor Merlin. These seemingly controversial results highlight that our understanding of Amot proteins in the Hippo pathway is so far limited.
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93069]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	Hong, Wanjin,Hong WJ. Angiomotin'g YAP into the Nucleus for Cell Proliferation and Cancer Development[J]. http://dx.doi.org/10.1126/scisignal.2004573,2013.
APA	Hong, Wanjin,&洪万进.(2013).Angiomotin'g YAP into the Nucleus for Cell Proliferation and Cancer Development.http://dx.doi.org/10.1126/scisignal.2004573.
MLA	Hong, Wanjin,et al."Angiomotin'g YAP into the Nucleus for Cell Proliferation and Cancer Development".http://dx.doi.org/10.1126/scisignal.2004573 (2013).