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	Artificial local magnetic field inhomogeneity enhances T2 relaxivity
	Zijian Zhou ; Zhou ZJ(周子健) ; Rui Tian ; Tian R(田蕊) ; Zhenyu Wang ; Zhen Yang ; Yijing Liu ; Gang Liu ; Ruifang Wang ; Wang RF(王瑞方) ; Jinhao Gao ; Gao JH(高锦豪) ; Jibin Song ; Liming Nie ; Nie LM(聂立铭) ; Xiaoyuan Chen ; Chen XY(陈小元)
	2017-05
英文摘要	磁性探针作为分子影像技术中的磁共振成像（MRI）造影剂在医学诊断中发挥着重要作用。为满足实际诊断中的准确性和精确性要求，科研工作者们长期致力于发展高性能的MRI造影剂以降低高剂量的使用带来的潜在风险。该文章指出了探针聚集体中局域磁场不均匀性是影响T2弛豫效能的关键因素。该文章首次利用磁场不均匀性因素阐明了单个探针和它们聚集体的MRI造影剂之间的相互关系，将可能成为弥补探针聚集体的造影剂理论的空白，并为发展新型高效的MRI造影剂提供重要参考。 该论文共同第一作者为博士后周子健和博士生田蕊，通讯作者为陈小元教授和聂立铭博士，部分工作得到我校物理学系王瑞方教授和化学化工学院高锦豪教授的支持。; 【Abstract】Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T2 relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r2 values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T2 relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T2 relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents.; This work was supported by the National Science Foundation of China (81571744 and 81601489), the National Basic Research Program of China (863 Program 2015AA020502), the Fundamental Research Funds for the Central Universities (20720170065), the Science Foundation of Fujian Province (No. 2014Y2004), and by the Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). 研究工作得到了国家自然科学基金委、国家高技术研究发展计划863项目、福建省重大研发平台项目和美国NIH Intramural Research Program的资助。
语种	中文
出版者	Macmillan Publishers Limited
内容类型	其他
源URL	[http://dspace.xmu.edu.cn/handle/2288/127776]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Zijian Zhou,Zhou ZJ,Rui Tian,et al. Artificial local magnetic field inhomogeneity enhances T2 relaxivity. 2017-05-01.

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