Dual imaging-guided photothermal/photodynamic therapy using micelles

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	Dual imaging-guided photothermal/photodynamic therapy using micelles
	Guo, Miao ; Mao, Huajian ; Li, Yanli ; Zhu, Aijun ; He, Hui ; Yang, Hong ; Wang, Yangyun ; Tian, Xin ; Ge, Cuicui ; Peng, Qiaoli ; Wang, Xianyong ; Yang, Xiangliang ; Chen, Xiaoyuan ; Liu, Gang ; Chen, Huabing ; Chen XY(陈小元) ; Liu G(刘刚)
刊名	http://dx.doi.org/10.1016/j.biomaterials.2014.02.018
	2014
关键词	RESPONSIVE GOLD NANOPARTICLES VIVO PHOTODYNAMIC THERAPY INDOCYANINE-GREEN INFRARED LIGHT CANCER-CELLS PHOTOTHERMAL THERAPY PHOTOSENSITIZER NANOSPHERES DOXORUBICIN DELIVERY
英文摘要	National Natural Science Foundation of China [81202472, 81101101, 51273165, 81371596]; National Basic Research Program [2012CB932500, 2013CB733802, 2014CB744503]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Program for New Century Excellent Talents in University [NCET-13-0502]; Fundamental Research Funds for the Central Universities [2013121039]; We report a type of photosensitizer (PS)-loaded micelles integrating cyanine dye as potential theranostic micelles for precise anatomical tumor localization via dual photoacoustic (PA)/near-infrared fluorescent (NIRF) imaging modalities, and simultaneously superior cancer therapy via sequential synergistic photothermal therapy (PTT)/photodynamic therapy (PDT). The micelles exhibit enhanced photostability, cell internalization and tumor accumulation. The dual NIRF/PA imaging modalities of the micelles cause the high imaging contrast and spatial resolution of tumors, which provide precise anatomical localization of the tumor and its inner vasculature for guiding PTT/PDT treatments. Moreover, the micelles can generate severe photothermal damage on cancer cells and destabilization of the lysosomes upon PTT photo-irradiation, which subsequently facilitate synergistic photodynamic injury via PS under PDT treatment. The sequential treatments of PTT/PDT trigger the enhanced cytoplasmic delivery of PS, which contributes to the synergistic anticancer efficacy of PS. Our strategy provides a dual-modal cancer imaging with high imaging contrast and spatial resolution, and subsequent therapeutic synergy of PTT/PDT for potential multimodal theranostic application. (C) 2014 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87583]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Guo, Miao,Mao, Huajian,Li, Yanli,et al. Dual imaging-guided photothermal/photodynamic therapy using micelles[J]. http://dx.doi.org/10.1016/j.biomaterials.2014.02.018,2014.
APA	Guo, Miao.,Mao, Huajian.,Li, Yanli.,Zhu, Aijun.,He, Hui.,...&刘刚.(2014).Dual imaging-guided photothermal/photodynamic therapy using micelles.http://dx.doi.org/10.1016/j.biomaterials.2014.02.018.
MLA	Guo, Miao,et al."Dual imaging-guided photothermal/photodynamic therapy using micelles".http://dx.doi.org/10.1016/j.biomaterials.2014.02.018 (2014).