Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen

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	Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen
	Liu, Dingbin ; Huang, Xinglu ; Wang, Zhantong ; Jin, Albert ; Sun, Xiaolian ; Zhu, Le ; Wang, Fu ; Ma, Ying ; Niu, Gang ; Hight Walker, Angela R. ; Chen, Xiaoyuan ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1021/nn401837q
	2013-06-25
关键词	Antigens Body fluids Diagnosis Fluorescence Gold Metal nanoparticles Urology
英文摘要	It is still in high demand to develop extremely sensitive and accurate clinical tools for biomarkers of interest for early diagnosis and monitoring of diseases. In this report, we present a highly sensitive and compatible gold nanoparticle (AuNP)-based fluorescence-activatable probe for sensing ultralow levels of prostate-specific antigen (PSA) in patient serum samples. The limit of detection of the newly developed probe for PSA was pushed down to 0.032 pg/mL, which is more than 2 orders of magnitude lower than that of the conventional fluorescence probe. The ultrahigh sensitivity of this probe was attributed to the high loading efficiency of the dyes on AuNP surfaces and high fluorescence quenching-unquenching abilities of the dye-AuNP pairs. The efficiency and robustness of this probe were investigated in patient serum samples, demonstrating the great potential of this probe in real-world applications. ? 2013 American Chemical Society.
语种	英语
出版者	American Chemical Society
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87576]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Liu, Dingbin,Huang, Xinglu,Wang, Zhantong,et al. Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen[J]. http://dx.doi.org/10.1021/nn401837q,2013.
APA	Liu, Dingbin.,Huang, Xinglu.,Wang, Zhantong.,Jin, Albert.,Sun, Xiaolian.,...&陈小元.(2013).Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen.http://dx.doi.org/10.1021/nn401837q.
MLA	Liu, Dingbin,et al."Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen".http://dx.doi.org/10.1021/nn401837q (2013).