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	Research of the Methylation Status of miR-124a Gene Promoter among Rheumatoid Arthritis Patients
	Zhou, Qiao ; Long, Li ; Shi, Guixiu ; Zhang, Jing ; Wu, Tong ; Zhou, Bin ; Shi GX(石桂秀)
刊名	http://dx.doi.org/10.1155/2013/524204
	2013
关键词	HUMAN CANCER MICRORNAS CLASSIFICATION PATHOGENESIS CRITERIA
英文摘要	National Natural Science Foundation of China [81102272]; Objective. To analyze the methylation status of miR-124a loci in synovial tissues of rheumatoid arthritis (RA) patients using methylation-specific polymerase chain reaction (MSP). Materials and Methods. DNA obtained from the frozen tissue of 7 RA samples, 6 osteoarthritis (OA) samples, and 3 healthy controls were undergoing bisulfite conversion and then analyzed for miR-124a promoter methylation using MSP assay. Results. miR-124-a1 and miR-124-a2 promoter methylation were both seen in 71.4% of RA samples compared to 16.7% of OA samples. miR-124-a3 promoter methylation was seen in 57.1% of RA samples and 0% of OA samples. All the three loci were unmethylated in 3 healthy controls. Conclusion. The methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis.
语种	英语
出版者	HINDAWI PUBLISHING CORPORATION
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93423]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhou, Qiao,Long, Li,Shi, Guixiu,et al. Research of the Methylation Status of miR-124a Gene Promoter among Rheumatoid Arthritis Patients[J]. http://dx.doi.org/10.1155/2013/524204,2013.
APA	Zhou, Qiao.,Long, Li.,Shi, Guixiu.,Zhang, Jing.,Wu, Tong.,...&石桂秀.(2013).Research of the Methylation Status of miR-124a Gene Promoter among Rheumatoid Arthritis Patients.http://dx.doi.org/10.1155/2013/524204.
MLA	Zhou, Qiao,et al."Research of the Methylation Status of miR-124a Gene Promoter among Rheumatoid Arthritis Patients".http://dx.doi.org/10.1155/2013/524204 (2013).

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